eF-site ID 5npp-D PDB Code 5npp Chain D click to enlarge Title 2.22A STRUCTURE OF THIOPHENE2 AND GSK945237 WITH S.AUREUS DNA GYRASE AND DNA Classification ISOMERASE Compound DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A Source Staphylococcus aureus (strain N315) (5NPP) Sequence D:  GKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAIL PLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDL AKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAG YVYIAQPPTGYKGLGEMNADQLWETTMNPEHRALLQVKLE DAIEADQTFEMLMGDVVENRRQFIEDNAVYNERNITSEMR ESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMT PDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSY RYPLVDGQGNFGSMDGDGAAAMRYTEARMTKITLELLRDI NKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIAVGM ATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFP TAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRI VVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLR TGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALV NGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKDRAH ILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSE KQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETIL ADEEVLLQLVRDELTEIRDRFGDDRRTEIQL Description Functional site 1) chain D residue 1315 type sequence S description binding site for residue GOL B 1503 source : AC3 2) chain D residue 1319 type sequence N description binding site for residue GOL B 1503 source : AC3 3) chain D residue 508 type sequence D description binding site for residue MN D 1501 source : AC8 4) chain D residue 510 type sequence D description binding site for residue MN D 1501 source : AC8 5) chain D residue 630 type sequence R description binding site for residue 94K D 1502 source : AC9 6) chain D residue 633 type sequence I description binding site for residue 94K D 1502 source : AC9 7) chain D residue 634 type sequence E description binding site for residue 94K D 1502 source : AC9 8) chain D residue 637 type sequence A description binding site for residue 94K D 1502 source : AC9 9) chain D residue 1031 type sequence V description binding site for residue 94K D 1502 source : AC9 10) chain D residue 1179 type sequence M description binding site for residue 94K D 1502 source : AC9 11) chain D residue 1342 type sequence R description binding site for residue 94K D 1502 source : AC9 12) chain D residue 1343 type sequence P description binding site for residue 94K D 1502 source : AC9 13) chain D residue 1044 type sequence P description binding site for residue GOL D 1503 source : AD1 14) chain D residue 1047 type sequence R description binding site for residue GOL D 1503 source : AD1 15) chain D residue 1156 type sequence E description binding site for residue GOL D 1503 source : AD1 16) chain D residue 1251 type sequence E description binding site for residue GOL D 1504 source : AD2 17) chain D residue 1255 type sequence G description binding site for residue GOL D 1504 source : AD2 18) chain D residue 1256 type sequence R description binding site for residue GOL D 1504 source : AD2 19) chain D residue 1257 type sequence Q description binding site for residue GOL D 1504 source : AD2 20) chain D residue 1115 type sequence G description binding site for residue GOL D 1505 source : AD3 21) chain D residue 1267 type sequence Q description binding site for residue GOL D 1505 source : AD3 22) chain D residue 1389 type sequence D description binding site for residue GOL D 1506 source : AD4 23) chain D residue 1390 type sequence H description binding site for residue GOL D 1506 source : AD4 24) chain D residue 1068 type sequence A description binding site for residue 6EJ C 101 source : AD6 25) chain D residue 1075 type sequence M description binding site for residue 6EJ C 101 source : AD6 26) chain D residue 1083 type sequence D description binding site for residue 6EJ C 101 source : AD6 27) chain D residue 1121 type sequence M description binding site for residue 6EJ C 101 source : AD6 28) chain D residue 1084 type sequence S description binding site for residue GOL C 102 source : AD7 29) chain D residue 435 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 508 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 510 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI1 32) chain D residue 460 type SITE sequence K description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI2 33) chain D residue 463 type SITE sequence N description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI2 34) chain D residue 1123 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 source Swiss-Prot : SWS_FT_FI3

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