eF-site ID 5npp-B PDB Code 5npp Chain B click to enlarge Title 2.22A STRUCTURE OF THIOPHENE2 AND GSK945237 WITH S.AUREUS DNA GYRASE AND DNA Classification ISOMERASE Compound DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A Source Staphylococcus aureus (strain N315) (5NPP) Sequence B:  KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILP LRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLA KARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGY VYIAQPPTGYKGLGEMNADQLWETTMNPEHRALLQVKLED AIEADQTFEMLMGDVVENRRQFIEDNAVYINERNITSEMR ESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMT PDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSY RYPLVDGQGNFGSMDGDGAAAMRYTEARMTKITLELLRDI NKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIAVGM ATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFP TAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRI VVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLR TGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALV NGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKDRAH ILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSE KQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETIL ADEEVLLQLVRDELTEIRDRFGDDRRTEIQLG Description (1)  DNA gyrase subunit B, DNA gyrase subunit A/DNA Complex Functional site 1) chain B residue 508 type sequence D description binding site for residue MN B 1501 source : AC1 2) chain B residue 510 type sequence D description binding site for residue MN B 1501 source : AC1 3) chain B residue 630 type sequence R description binding site for residue 94K B 1502 source : AC2 4) chain B residue 633 type sequence I description binding site for residue 94K B 1502 source : AC2 5) chain B residue 634 type sequence E description binding site for residue 94K B 1502 source : AC2 6) chain B residue 1031 type sequence V description binding site for residue 94K B 1502 source : AC2 7) chain B residue 1179 type sequence M description binding site for residue 94K B 1502 source : AC2 8) chain B residue 1342 type sequence R description binding site for residue 94K B 1502 source : AC2 9) chain B residue 1343 type sequence P description binding site for residue 94K B 1502 source : AC2 10) chain B residue 1251 type sequence E description binding site for residue GOL B 1503 source : AC3 11) chain B residue 1255 type sequence G description binding site for residue GOL B 1503 source : AC3 12) chain B residue 1256 type sequence R description binding site for residue GOL B 1503 source : AC3 13) chain B residue 1047 type sequence R description binding site for residue GOL B 1504 source : AC4 14) chain B residue 1048 type sequence R description binding site for residue GOL B 1504 source : AC4 15) chain B residue 1147 type sequence I description binding site for residue GOL B 1504 source : AC4 16) chain B residue 1156 type sequence E description binding site for residue GOL B 1504 source : AC4 17) chain B residue 1190 type sequence E description binding site for residue GOL B 1505 source : AC5 18) chain B residue 1214 type sequence E description binding site for residue GOL B 1505 source : AC5 19) chain B residue 1482 type sequence D description binding site for residue GOL B 1505 source : AC5 20) chain B residue 1483 type sequence D description binding site for residue GOL B 1505 source : AC5 21) chain B residue 1484 type sequence R description binding site for residue GOL B 1505 source : AC5 22) chain B residue 1322 type sequence Y description binding site for residue NA B 1506 source : AC6 23) chain B residue 1323 type sequence K description binding site for residue NA B 1506 source : AC6 24) chain B residue 1325 type sequence T description binding site for residue NA B 1506 source : AC6 25) chain B residue 1328 type sequence Q description binding site for residue NA B 1506 source : AC6 26) chain B residue 1097 type sequence F description binding site for residue DMS B 1507 source : AC7 27) chain B residue 1113 type sequence M description binding site for residue DMS B 1507 source : AC7 28) chain B residue 1115 type sequence G description binding site for residue DMS B 1507 source : AC7 29) chain B residue 1244 type sequence R description binding site for residue GOL D 1504 source : AD2 30) chain B residue 1319 type sequence N description binding site for residue GOL D 1504 source : AD2 31) chain B residue 1084 type sequence S description binding site for residue GOL A 101 source : AD5 32) chain B residue 1068 type sequence A description binding site for residue 6EJ C 101 source : AD6 33) chain B residue 1072 type sequence G description binding site for residue 6EJ C 101 source : AD6 34) chain B residue 1075 type sequence M description binding site for residue 6EJ C 101 source : AD6 35) chain B residue 1083 type sequence D description binding site for residue 6EJ C 101 source : AD6 36) chain B residue 1121 type sequence M description binding site for residue 6EJ C 101 source : AD6 37) chain B residue 433-441 type prosite sequence LVEGDSAGG description TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG source prosite : PS00177 38) chain B residue 510 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 508 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 435 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 463 type SITE sequence N description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 460 type SITE sequence K description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 1123 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 source Swiss-Prot : SWS_FT_FI3

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