eF-site ID 5nne-A PDB Code 5nne Chain A click to enlarge Title Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated TOP2A peptide (K1201ac/K1204ac) Classification TRANSCRIPTION Compound Bromodomain-containing protein 4 Source (5NNE) Sequence A:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPT Description Functional site 1) chain A residue 42 type sequence S description binding site for residue EDO A 201 source : AC1 2) chain A residue 43 type sequence M description binding site for residue EDO A 201 source : AC1 3) chain A residue 44 type sequence N description binding site for residue EDO A 201 source : AC1 4) chain A residue 52 type sequence N description binding site for residue EDO A 201 source : AC1 5) chain A residue 118 type sequence Y description binding site for residue EDO A 201 source : AC1 6) chain A residue 120 type sequence W description binding site for residue EDO A 201 source : AC1 7) chain A residue 80-139 type prosite sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY WNAQECIQDFNTMFTNCYIY description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY source prosite : PS00633

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