eF-site ID 5njv-C PDB Code 5njv Chain C click to enlarge Title Flavivirus NS5 domain Classification VIRAL PROTEIN Compound NS5 Source Zika virus (strain Mr 766) (ZIKV) (A0A146CJG7_ZIKV) Sequence C:  GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRGV ATGGHAVSRGSAKLRWLVDRGYLQPYGKVIDLGCGRGGWS YYAATIRKVQEVKGYTKGGPGHEEPVLVQSYGWNIVRLKS GVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMV GDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVR VPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPR RPVKYEEDVNLGSGTR Description Functional site 1) chain C residue 56 type sequence S description binding site for residue SAM C 301 source : AC7 2) chain C residue 58 type sequence G description binding site for residue SAM C 301 source : AC7 3) chain C residue 81 type sequence G description binding site for residue SAM C 301 source : AC7 4) chain C residue 82 type sequence C description binding site for residue SAM C 301 source : AC7 5) chain C residue 83 type sequence G description binding site for residue SAM C 301 source : AC7 6) chain C residue 86 type sequence G description binding site for residue SAM C 301 source : AC7 7) chain C residue 87 type sequence W description binding site for residue SAM C 301 source : AC7 8) chain C residue 104 type sequence T description binding site for residue SAM C 301 source : AC7 9) chain C residue 105 type sequence K description binding site for residue SAM C 301 source : AC7 10) chain C residue 110 type sequence H description binding site for residue SAM C 301 source : AC7 11) chain C residue 111 type sequence E description binding site for residue SAM C 301 source : AC7 12) chain C residue 130 type sequence V description binding site for residue SAM C 301 source : AC7 13) chain C residue 131 type sequence D description binding site for residue SAM C 301 source : AC7 14) chain C residue 132 type sequence V description binding site for residue SAM C 301 source : AC7 15) chain C residue 133 type sequence F description binding site for residue SAM C 301 source : AC7 16) chain C residue 146 type sequence D description binding site for residue SAM C 301 source : AC7 17) chain C residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 18) chain C residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 19) chain C residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 21) chain C residue 13 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 22) chain C residue 149 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 23) chain C residue 213 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 24) chain C residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 25) chain C residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 26) chain C residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 27) chain C residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 28) chain C residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 29) chain C residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 30) chain C residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 31) chain C residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 32) chain C residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 33) chain C residue 110 type BINDING sequence H description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 34) chain C residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 35) chain C residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 36) chain C residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 37) chain C residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 38) chain C residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 39) chain C residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 40) chain C residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 41) chain C residue 28 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 42) chain C residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 43) chain C residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 44) chain C residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 45) chain C residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 46) chain C residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 47) chain C residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 48) chain C residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 49) chain C residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9

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