eF-site ID 5njv-B PDB Code 5njv Chain B click to enlarge Title Flavivirus NS5 domain Classification VIRAL PROTEIN Compound NS5 Source Zika virus (strain Mr 766) (ZIKV) (A0A146CJG7_ZIKV) Sequence B:  TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRA LKDGVATGGHAVSRGSAKLRWLVDRGYLQPYGKVIDLGCG RGGWSYYAATIRKVQEVKGYTKGGPGHEEPVLVQSYGWNI VRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLR VLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYG GGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGR MDGPRRPVKYEEDVNLGSGTRA Description Functional site 1) chain B residue 56 type sequence S description binding site for residue SAM B 301 source : AC4 2) chain B residue 58 type sequence G description binding site for residue SAM B 301 source : AC4 3) chain B residue 81 type sequence G description binding site for residue SAM B 301 source : AC4 4) chain B residue 82 type sequence C description binding site for residue SAM B 301 source : AC4 5) chain B residue 83 type sequence G description binding site for residue SAM B 301 source : AC4 6) chain B residue 86 type sequence G description binding site for residue SAM B 301 source : AC4 7) chain B residue 87 type sequence W description binding site for residue SAM B 301 source : AC4 8) chain B residue 104 type sequence T description binding site for residue SAM B 301 source : AC4 9) chain B residue 105 type sequence K description binding site for residue SAM B 301 source : AC4 10) chain B residue 110 type sequence H description binding site for residue SAM B 301 source : AC4 11) chain B residue 111 type sequence E description binding site for residue SAM B 301 source : AC4 12) chain B residue 130 type sequence V description binding site for residue SAM B 301 source : AC4 13) chain B residue 131 type sequence D description binding site for residue SAM B 301 source : AC4 14) chain B residue 132 type sequence V description binding site for residue SAM B 301 source : AC4 15) chain B residue 133 type sequence F description binding site for residue SAM B 301 source : AC4 16) chain B residue 146 type sequence D description binding site for residue SAM B 301 source : AC4 17) chain B residue 7 type sequence T description binding site for residue CL B 302 source : AC5 18) chain B residue 8 type sequence L description binding site for residue CL B 302 source : AC5 19) chain B residue 148 type sequence G description binding site for residue CL B 303 source : AC6 20) chain B residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 25) chain B residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 26) chain B residue 13 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 149 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 213 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 32) chain B residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 33) chain B residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 34) chain B residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 35) chain B residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 110 type BINDING sequence H description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 37) chain B residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 38) chain B residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 39) chain B residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 40) chain B residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 41) chain B residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 42) chain B residue 28 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 43) chain B residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 44) chain B residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 45) chain B residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 46) chain B residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 47) chain B residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 48) chain B residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 49) chain B residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 50) chain B residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 51) chain B residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 52) chain B residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9

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