eF-site ID 5njv-ABCD PDB Code 5njv Chain A, B, C, D click to enlarge Title Flavivirus NS5 domain Classification VIRAL PROTEIN Compound NS5 Source Zika virus (strain Mr 766) (ZIKV) (A0A146CJG7_ZIKV) Sequence A:  TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRA LKDGVATGGHAVSRGSAKLRWLVDRGYLQPYGKVIDLGCG RGGWSYYAATIRKVQEVKGYTKGGPGHEEPVLVQSYGWNI VRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLR VLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYG GGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGR MDGPRRPVKYEEDVNLGSGTR B:  TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRA LKDGVATGGHAVSRGSAKLRWLVDRGYLQPYGKVIDLGCG RGGWSYYAATIRKVQEVKGYTKGGPGHEEPVLVQSYGWNI VRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLR VLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYG GGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGR MDGPRRPVKYEEDVNLGSGTRA C:  GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRGV ATGGHAVSRGSAKLRWLVDRGYLQPYGKVIDLGCGRGGWS YYAATIRKVQEVKGYTKGGPGHEEPVLVQSYGWNIVRLKS GVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMV GDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVR VPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPR RPVKYEEDVNLGSGTR D:  TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRA ATGGHAVSRGSAKLRWLVDRGYLQPYGKVIDLGCGRGGWS YYAATIRKVQEVKGYTKGGPGHEEPVLVQSYGWNIVRLKS GVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMV GDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVR VPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPR RPVKYEEDVNLGSGTR Description Functional site 1) chain A residue 56 type sequence S description binding site for residue SAM A 301 source : AC1 2) chain A residue 58 type sequence G description binding site for residue SAM A 301 source : AC1 3) chain A residue 81 type sequence G description binding site for residue SAM A 301 source : AC1 4) chain A residue 82 type sequence C description binding site for residue SAM A 301 source : AC1 5) chain A residue 83 type sequence G description binding site for residue SAM A 301 source : AC1 6) chain A residue 86 type sequence G description binding site for residue SAM A 301 source : AC1 7) chain A residue 87 type sequence W description binding site for residue SAM A 301 source : AC1 8) chain A residue 104 type sequence T description binding site for residue SAM A 301 source : AC1 9) chain A residue 105 type sequence K description binding site for residue SAM A 301 source : AC1 10) chain A residue 110 type sequence H description binding site for residue SAM A 301 source : AC1 11) chain A residue 111 type sequence E description binding site for residue SAM A 301 source : AC1 12) chain A residue 130 type sequence V description binding site for residue SAM A 301 source : AC1 13) chain A residue 131 type sequence D description binding site for residue SAM A 301 source : AC1 14) chain A residue 132 type sequence V description binding site for residue SAM A 301 source : AC1 15) chain A residue 133 type sequence F description binding site for residue SAM A 301 source : AC1 16) chain A residue 146 type sequence D description binding site for residue SAM A 301 source : AC1 17) chain A residue 148 type sequence G description binding site for residue CL A 302 source : AC2 18) chain A residue 149 type sequence E description binding site for residue CL A 302 source : AC2 19) chain A residue 148 type sequence G description binding site for residue CL A 303 source : AC3 20) chain A residue 149 type sequence E description binding site for residue CL A 303 source : AC3 21) chain B residue 56 type sequence S description binding site for residue SAM B 301 source : AC4 22) chain B residue 58 type sequence G description binding site for residue SAM B 301 source : AC4 23) chain B residue 81 type sequence G description binding site for residue SAM B 301 source : AC4 24) chain B residue 82 type sequence C description binding site for residue SAM B 301 source : AC4 25) chain B residue 83 type sequence G description binding site for residue SAM B 301 source : AC4 26) chain B residue 86 type sequence G description binding site for residue SAM B 301 source : AC4 27) chain B residue 87 type sequence W description binding site for residue SAM B 301 source : AC4 28) chain B residue 104 type sequence T description binding site for residue SAM B 301 source : AC4 29) chain B residue 105 type sequence K description binding site for residue SAM B 301 source : AC4 30) chain B residue 110 type sequence H description binding site for residue SAM B 301 source : AC4 31) chain B residue 111 type sequence E description binding site for residue SAM B 301 source : AC4 32) chain B residue 130 type sequence V description binding site for residue SAM B 301 source : AC4 33) chain B residue 131 type sequence D description binding site for residue SAM B 301 source : AC4 34) chain B residue 132 type sequence V description binding site for residue SAM B 301 source : AC4 35) chain B residue 133 type sequence F description binding site for residue SAM B 301 source : AC4 36) chain B residue 146 type sequence D description binding site for residue SAM B 301 source : AC4 37) chain B residue 7 type sequence T description binding site for residue CL B 302 source : AC5 38) chain B residue 8 type sequence L description binding site for residue CL B 302 source : AC5 39) chain B residue 148 type sequence G description binding site for residue CL B 303 source : AC6 40) chain C residue 56 type sequence S description binding site for residue SAM C 301 source : AC7 41) chain C residue 58 type sequence G description binding site for residue SAM C 301 source : AC7 42) chain C residue 81 type sequence G description binding site for residue SAM C 301 source : AC7 43) chain C residue 82 type sequence C description binding site for residue SAM C 301 source : AC7 44) chain C residue 83 type sequence G description binding site for residue SAM C 301 source : AC7 45) chain C residue 86 type sequence G description binding site for residue SAM C 301 source : AC7 46) chain C residue 87 type sequence W description binding site for residue SAM C 301 source : AC7 47) chain C residue 104 type sequence T description binding site for residue SAM C 301 source : AC7 48) chain C residue 105 type sequence K description binding site for residue SAM C 301 source : AC7 49) chain C residue 110 type sequence H description binding site for residue SAM C 301 source : AC7 50) chain C residue 111 type sequence E description binding site for residue SAM C 301 source : AC7 51) chain C residue 130 type sequence V description binding site for residue SAM C 301 source : AC7 52) chain C residue 131 type sequence D description binding site for residue SAM C 301 source : AC7 53) chain C residue 132 type sequence V description binding site for residue SAM C 301 source : AC7 54) chain C residue 133 type sequence F description binding site for residue SAM C 301 source : AC7 55) chain C residue 146 type sequence D description binding site for residue SAM C 301 source : AC7 56) chain D residue 56 type sequence S description binding site for residue SAM D 301 source : AC8 57) chain D residue 58 type sequence G description binding site for residue SAM D 301 source : AC8 58) chain D residue 81 type sequence G description binding site for residue SAM D 301 source : AC8 59) chain D residue 82 type sequence C description binding site for residue SAM D 301 source : AC8 60) chain D residue 83 type sequence G description binding site for residue SAM D 301 source : AC8 61) chain D residue 86 type sequence G description binding site for residue SAM D 301 source : AC8 62) chain D residue 87 type sequence W description binding site for residue SAM D 301 source : AC8 63) chain D residue 104 type sequence T description binding site for residue SAM D 301 source : AC8 64) chain D residue 105 type sequence K description binding site for residue SAM D 301 source : AC8 65) chain D residue 110 type sequence H description binding site for residue SAM D 301 source : AC8 66) chain D residue 111 type sequence E description binding site for residue SAM D 301 source : AC8 67) chain D residue 130 type sequence V description binding site for residue SAM D 301 source : AC8 68) chain D residue 131 type sequence D description binding site for residue SAM D 301 source : AC8 69) chain D residue 132 type sequence V description binding site for residue SAM D 301 source : AC8 70) chain D residue 133 type sequence F description binding site for residue SAM D 301 source : AC8 71) chain D residue 146 type sequence D description binding site for residue SAM D 301 source : AC8 72) chain D residue 147 type sequence I description binding site for residue SAM D 301 source : AC8 73) chain A residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 74) chain B residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 75) chain C residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 76) chain D residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 77) chain A residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 78) chain B residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 79) chain C residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 80) chain D residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 81) chain D residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 82) chain D residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 83) chain D residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 84) chain D residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 85) chain A residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 86) chain C residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 87) chain C residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 88) chain C residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 89) chain A residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 90) chain A residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 91) chain A residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 92) chain B residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 93) chain B residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 94) chain B residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 95) chain B residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 96) chain C residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 97) chain A residue 213 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 13 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 99) chain B residue 149 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 100) chain B residue 213 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 101) chain C residue 13 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 102) chain C residue 149 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 103) chain C residue 213 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 104) chain D residue 13 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 105) chain D residue 149 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 106) chain D residue 213 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 107) chain A residue 13 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 108) chain A residue 149 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 109) chain A residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 110) chain A residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 111) chain B residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 112) chain B residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 113) chain C residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 114) chain C residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 115) chain D residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 116) chain D residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 117) chain D residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 118) chain D residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 119) chain D residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 120) chain D residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 121) chain A residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 122) chain A residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 123) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 124) chain A residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 125) chain B residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 126) chain B residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 127) chain B residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 128) chain B residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 129) chain B residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 130) chain C residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 131) chain C residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 132) chain C residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 133) chain C residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 134) chain C residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 135) chain D residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 136) chain A residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 137) chain A residue 110 type BINDING sequence H description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 138) chain A residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 139) chain A residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 140) chain B residue 110 type BINDING sequence H description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 141) chain B residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 142) chain B residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 143) chain C residue 110 type BINDING sequence H description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 144) chain C residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 145) chain C residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 146) chain D residue 110 type BINDING sequence H description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 147) chain D residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 148) chain D residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 149) chain C residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 150) chain C residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 151) chain D residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 152) chain D residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 153) chain A residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 154) chain A residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 155) chain B residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 156) chain B residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 157) chain B residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 158) chain B residue 28 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 159) chain B residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 160) chain B residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 161) chain B residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 162) chain C residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 163) chain C residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 164) chain C residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 165) chain C residue 28 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 166) chain C residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 167) chain C residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 168) chain C residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 169) chain D residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 170) chain D residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 171) chain D residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 172) chain D residue 28 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 173) chain D residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 174) chain D residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 175) chain D residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 176) chain B residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 177) chain A residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 178) chain A residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 179) chain A residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 180) chain A residue 28 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 181) chain A residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 182) chain A residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 183) chain A residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 184) chain B residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 185) chain C residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 186) chain C residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 187) chain D residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 188) chain D residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 189) chain A residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 190) chain A residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 191) chain B residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 192) chain B residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 193) chain D residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 194) chain D residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 195) chain D residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 196) chain C residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 197) chain A residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 198) chain A residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 199) chain A residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 200) chain B residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 201) chain B residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 202) chain B residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 203) chain C residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 204) chain C residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9

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