eF-site ID 5njv-A
PDB Code 5njv
Chain A

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Title Flavivirus NS5 domain
Classification VIRAL PROTEIN
Compound NS5
Source Zika virus (strain Mr 766) (ZIKV) (A0A146CJG7_ZIKV)
Sequence A:  TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRA
LKDGVATGGHAVSRGSAKLRWLVDRGYLQPYGKVIDLGCG
RGGWSYYAATIRKVQEVKGYTKGGPGHEEPVLVQSYGWNI
VRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLR
VLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYG
GGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGR
MDGPRRPVKYEEDVNLGSGTR
Description


Functional site

1) chain A
residue 56
type
sequence S
description binding site for residue SAM A 301
source : AC1

2) chain A
residue 58
type
sequence G
description binding site for residue SAM A 301
source : AC1

3) chain A
residue 81
type
sequence G
description binding site for residue SAM A 301
source : AC1

4) chain A
residue 82
type
sequence C
description binding site for residue SAM A 301
source : AC1

5) chain A
residue 83
type
sequence G
description binding site for residue SAM A 301
source : AC1

6) chain A
residue 86
type
sequence G
description binding site for residue SAM A 301
source : AC1

7) chain A
residue 87
type
sequence W
description binding site for residue SAM A 301
source : AC1

8) chain A
residue 104
type
sequence T
description binding site for residue SAM A 301
source : AC1

9) chain A
residue 105
type
sequence K
description binding site for residue SAM A 301
source : AC1

10) chain A
residue 110
type
sequence H
description binding site for residue SAM A 301
source : AC1

11) chain A
residue 111
type
sequence E
description binding site for residue SAM A 301
source : AC1

12) chain A
residue 130
type
sequence V
description binding site for residue SAM A 301
source : AC1

13) chain A
residue 131
type
sequence D
description binding site for residue SAM A 301
source : AC1

14) chain A
residue 132
type
sequence V
description binding site for residue SAM A 301
source : AC1

15) chain A
residue 133
type
sequence F
description binding site for residue SAM A 301
source : AC1

16) chain A
residue 146
type
sequence D
description binding site for residue SAM A 301
source : AC1

17) chain A
residue 148
type
sequence G
description binding site for residue CL A 302
source : AC2

18) chain A
residue 149
type
sequence E
description binding site for residue CL A 302
source : AC2

19) chain A
residue 148
type
sequence G
description binding site for residue CL A 303
source : AC3

20) chain A
residue 149
type
sequence E
description binding site for residue CL A 303
source : AC3

21) chain A
residue 61
type ACT_SITE
sequence K
description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
source Swiss-Prot : SWS_FT_FI1

22) chain A
residue 146
type ACT_SITE
sequence D
description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 182
type ACT_SITE
sequence K
description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
source Swiss-Prot : SWS_FT_FI1

24) chain A
residue 218
type ACT_SITE
sequence E
description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
source Swiss-Prot : SWS_FT_FI1

25) chain A
residue 146
type SITE
sequence D
description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI10

26) chain A
residue 56
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P03314
source Swiss-Prot : SWS_FT_FI11

27) chain A
residue 13
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:27866982
source Swiss-Prot : SWS_FT_FI2

28) chain A
residue 149
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:27866982
source Swiss-Prot : SWS_FT_FI2

29) chain A
residue 213
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:27866982
source Swiss-Prot : SWS_FT_FI2

30) chain A
residue 56
type BINDING
sequence S
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982
source Swiss-Prot : SWS_FT_FI3

31) chain A
residue 104
type BINDING
sequence T
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982
source Swiss-Prot : SWS_FT_FI3

32) chain A
residue 86
type BINDING
sequence G
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
source Swiss-Prot : SWS_FT_FI4

33) chain A
residue 87
type BINDING
sequence W
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
source Swiss-Prot : SWS_FT_FI4

34) chain A
residue 105
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
source Swiss-Prot : SWS_FT_FI4

35) chain A
residue 131
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
source Swiss-Prot : SWS_FT_FI4

36) chain A
residue 132
type BINDING
sequence V
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
source Swiss-Prot : SWS_FT_FI4

37) chain A
residue 110
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
source Swiss-Prot : SWS_FT_FI5

38) chain A
residue 111
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
source Swiss-Prot : SWS_FT_FI5

39) chain A
residue 146
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
source Swiss-Prot : SWS_FT_FI5

40) chain A
residue 147
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI6

41) chain A
residue 220
type BINDING
sequence Y
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI6

42) chain A
residue 13
type SITE
sequence K
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI7

43) chain A
residue 17
type SITE
sequence N
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI7

44) chain A
residue 24
type SITE
sequence F
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI7

45) chain A
residue 28
type SITE
sequence K
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI7

46) chain A
residue 150
type SITE
sequence S
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI7

47) chain A
residue 213
type SITE
sequence R
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI7

48) chain A
residue 215
type SITE
sequence S
description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI7

49) chain A
residue 16
type SITE
sequence L
description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI8

50) chain A
residue 19
type SITE
sequence M
description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI8

51) chain A
residue 61
type SITE
sequence K
description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI9

52) chain A
residue 182
type SITE
sequence K
description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI9

53) chain A
residue 218
type SITE
sequence E
description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
source Swiss-Prot : SWS_FT_FI9


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