eF-site ID 5njv-A PDB Code 5njv Chain A click to enlarge Title Flavivirus NS5 domain Classification VIRAL PROTEIN Compound NS5 Source Zika virus (strain Mr 766) (ZIKV) (A0A146CJG7_ZIKV) Sequence A:  TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRA LKDGVATGGHAVSRGSAKLRWLVDRGYLQPYGKVIDLGCG RGGWSYYAATIRKVQEVKGYTKGGPGHEEPVLVQSYGWNI VRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLR VLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYG GGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGR MDGPRRPVKYEEDVNLGSGTR Description Functional site 1) chain A residue 56 type sequence S description binding site for residue SAM A 301 source : AC1 2) chain A residue 58 type sequence G description binding site for residue SAM A 301 source : AC1 3) chain A residue 81 type sequence G description binding site for residue SAM A 301 source : AC1 4) chain A residue 82 type sequence C description binding site for residue SAM A 301 source : AC1 5) chain A residue 83 type sequence G description binding site for residue SAM A 301 source : AC1 6) chain A residue 86 type sequence G description binding site for residue SAM A 301 source : AC1 7) chain A residue 87 type sequence W description binding site for residue SAM A 301 source : AC1 8) chain A residue 104 type sequence T description binding site for residue SAM A 301 source : AC1 9) chain A residue 105 type sequence K description binding site for residue SAM A 301 source : AC1 10) chain A residue 110 type sequence H description binding site for residue SAM A 301 source : AC1 11) chain A residue 111 type sequence E description binding site for residue SAM A 301 source : AC1 12) chain A residue 130 type sequence V description binding site for residue SAM A 301 source : AC1 13) chain A residue 131 type sequence D description binding site for residue SAM A 301 source : AC1 14) chain A residue 132 type sequence V description binding site for residue SAM A 301 source : AC1 15) chain A residue 133 type sequence F description binding site for residue SAM A 301 source : AC1 16) chain A residue 146 type sequence D description binding site for residue SAM A 301 source : AC1 17) chain A residue 148 type sequence G description binding site for residue CL A 302 source : AC2 18) chain A residue 149 type sequence E description binding site for residue CL A 302 source : AC2 19) chain A residue 148 type sequence G description binding site for residue CL A 303 source : AC3 20) chain A residue 149 type sequence E description binding site for residue CL A 303 source : AC3 21) chain A residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 26) chain A residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 27) chain A residue 13 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 149 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 213 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 36) chain A residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI4 37) chain A residue 110 type BINDING sequence H description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 38) chain A residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 39) chain A residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 source Swiss-Prot : SWS_FT_FI5 40) chain A residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 41) chain A residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 42) chain A residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 43) chain A residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 44) chain A residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 45) chain A residue 28 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 46) chain A residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 47) chain A residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 48) chain A residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 49) chain A residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 50) chain A residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI8 51) chain A residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 52) chain A residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 53) chain A residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9

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