eF-site ID 5naw-A PDB Code 5naw Chain A click to enlarge Title Complement factor D in complex with the inhibitor (1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-trifluoromethoxy-phenyl)-amide] Classification HYDROLASE Compound Complement factor D Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYAAWIDSVLA Description (1)  Complement factor D (E.C.3.4.21.46) Functional site 1) chain A residue 40 type sequence H description binding site for residue 8RZ A 301 source : AC1 2) chain A residue 41 type sequence L description binding site for residue 8RZ A 301 source : AC1 3) chain A residue 57 type sequence H description binding site for residue 8RZ A 301 source : AC1 4) chain A residue 58 type sequence C description binding site for residue 8RZ A 301 source : AC1 5) chain A residue 141 type sequence W description binding site for residue 8RZ A 301 source : AC1 6) chain A residue 142 type sequence G description binding site for residue 8RZ A 301 source : AC1 7) chain A residue 143 type sequence I description binding site for residue 8RZ A 301 source : AC1 8) chain A residue 151 type sequence R description binding site for residue 8RZ A 301 source : AC1 9) chain A residue 190 type sequence S description binding site for residue 8RZ A 301 source : AC1 10) chain A residue 191 type sequence C description binding site for residue 8RZ A 301 source : AC1 11) chain A residue 192 type sequence K description binding site for residue 8RZ A 301 source : AC1 12) chain A residue 193 type sequence G description binding site for residue 8RZ A 301 source : AC1 13) chain A residue 195 type sequence S description binding site for residue 8RZ A 301 source : AC1 14) chain A residue 213 type sequence V description binding site for residue 8RZ A 301 source : AC1 15) chain A residue 214 type sequence T description binding site for residue 8RZ A 301 source : AC1 16) chain A residue 215 type sequence S description binding site for residue 8RZ A 301 source : AC1 17) chain A residue 216 type sequence G description binding site for residue 8RZ A 301 source : AC1 18) chain A residue 217 type sequence S description binding site for residue 8RZ A 301 source : AC1 19) chain A residue 218 type sequence R description binding site for residue 8RZ A 301 source : AC1 20) chain A residue 220 type sequence C description binding site for residue 8RZ A 301 source : AC1 21) chain A residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 22) chain A residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 23) chain A residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 24) chain A residue 53-58 type prosite sequence LSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC source prosite : PS00134 25) chain A residue 189-200 type prosite sequence DSCKGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV source prosite : PS00135

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