eF-site ID 5nar-A
PDB Code 5nar
Chain A

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Title Complement factor D in complex with the inhibitor (S)-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]
Classification HYDROLASE
Compound Complement factor D
Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence A:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA
HCLEGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPD
TIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCD
VAGWGIVNHAGRRPDSLQHVLLPVLDRATCNTERLMCAES
NRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIY
TRVASYAAWIDSVLASA
Description (1)  Complement factor D (E.C.3.4.21.46)


Functional site

1) chain A
residue 25
type
sequence H
description binding site for residue SO4 A 301
source : AC1

2) chain A
residue 77
type
sequence E
description binding site for residue SO4 A 301
source : AC1

3) chain A
residue 202
type
sequence G
description binding site for residue SO4 A 301
source : AC1

4) chain A
residue 40
type
sequence H
description binding site for residue 8RW A 302
source : AC2

5) chain A
residue 41
type
sequence L
description binding site for residue 8RW A 302
source : AC2

6) chain A
residue 141
type
sequence W
description binding site for residue 8RW A 302
source : AC2

7) chain A
residue 142
type
sequence G
description binding site for residue 8RW A 302
source : AC2

8) chain A
residue 143
type
sequence I
description binding site for residue 8RW A 302
source : AC2

9) chain A
residue 151
type
sequence R
description binding site for residue 8RW A 302
source : AC2

10) chain A
residue 191
type
sequence C
description binding site for residue 8RW A 302
source : AC2

11) chain A
residue 192
type
sequence K
description binding site for residue 8RW A 302
source : AC2

12) chain A
residue 193
type
sequence G
description binding site for residue 8RW A 302
source : AC2

13) chain A
residue 195
type
sequence S
description binding site for residue 8RW A 302
source : AC2

14) chain A
residue 214
type
sequence T
description binding site for residue 8RW A 302
source : AC2

15) chain A
residue 215
type
sequence S
description binding site for residue 8RW A 302
source : AC2

16) chain A
residue 216
type
sequence G
description binding site for residue 8RW A 302
source : AC2

17) chain A
residue 218
type
sequence R
description binding site for residue 8RW A 302
source : AC2

18) chain A
residue 220
type
sequence C
description binding site for residue 8RW A 302
source : AC2

19) chain A
residue 57
type ACT_SITE
sequence H
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

20) chain A
residue 102
type ACT_SITE
sequence D
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 195
type ACT_SITE
sequence S
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

22) chain A
residue 53-58
type prosite
sequence LSAAHC
description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
source prosite : PS00134

23) chain A
residue 189-200
type prosite
sequence DSCKGDSGGPLV
description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
source prosite : PS00135


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