eF-site ID 5mur-ABCDE PDB Code 5mur Chain A, B, C, D, E click to enlarge Title X-ray structure of the F14'A mutant of GLIC in complex with propofol Classification TRANSPORT PROTEIN Compound Proton-gated ion channel Source (GLIC_GLOVI) Sequence A:  VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLS LSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENA RDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQ TLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIES FTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAANILVET NLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQ PARAASITRASRIAFPVVFLLANIILAFLFF B:  VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLS LSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENA RDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQ TLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIES FTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAANILVET NLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQ PARAASITRASRIAFPVVFLLANIILAFLFF C:  VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLS LSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENA RDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQ TLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIES FTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAANILVET NLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQ PARAASITRASRIAFPVVFLLANIILAFLFF D:  VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLS LSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENA RDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQ TLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIES FTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAANILVET NLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQ PARAASITRASRIAFPVVFLLANIILAFLFF E:  VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLS LSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENA RDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQ TLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIES FTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAANILVET NLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQ PARAASITRASRIAFPVVFLLANIILAFLFF Description Functional site 1) chain A residue 74 type sequence P description binding site for residue ACT A 401 source : AC1 2) chain A residue 76 type sequence I description binding site for residue ACT A 401 source : AC1 3) chain A residue 85 type sequence R description binding site for residue ACT A 401 source : AC1 4) chain A residue 102 type sequence Y description binding site for residue ACT A 401 source : AC1 5) chain A residue 78 type sequence F description binding site for residue CL A 402 source : AC2 6) chain A residue 85 type sequence R description binding site for residue CL A 402 source : AC2 7) chain A residue 68 type sequence P description binding site for residue NA A 403 source : AC3 8) chain A residue 71 type sequence I description binding site for residue NA A 403 source : AC3 9) chain A residue 118 type sequence R description binding site for residue PLC A 404 source : AC4 10) chain A residue 121 type sequence F description binding site for residue PLC A 404 source : AC4 11) chain A residue 194 type sequence Y description binding site for residue PLC A 404 source : AC4 12) chain A residue 254 type sequence Y description binding site for residue PLC A 404 source : AC4 13) chain A residue 307 type sequence N description binding site for residue PLC A 404 source : AC4 14) chain A residue 42 type sequence F description binding site for residue ACT A 405 source : AC5 15) chain A residue 105 type sequence R description binding site for residue ACT A 405 source : AC5 16) chain B residue 77 type sequence R description binding site for residue ACT A 405 source : AC5 17) chain B residue 131 type sequence I description binding site for residue ACT A 405 source : AC5 18) chain B residue 181 type sequence E description binding site for residue ACT A 405 source : AC5 19) chain B residue 74 type sequence P description binding site for residue ACT B 401 source : AC6 20) chain B residue 76 type sequence I description binding site for residue ACT B 401 source : AC6 21) chain B residue 85 type sequence R description binding site for residue ACT B 401 source : AC6 22) chain B residue 102 type sequence Y description binding site for residue ACT B 401 source : AC6 23) chain B residue 78 type sequence F description binding site for residue CL B 402 source : AC7 24) chain B residue 68 type sequence P description binding site for residue NA B 403 source : AC8 25) chain B residue 71 type sequence I description binding site for residue NA B 403 source : AC8 26) chain B residue 73 type sequence I description binding site for residue NA B 403 source : AC8 27) chain B residue 118 type sequence R description binding site for residue PLC B 404 source : AC9 28) chain B residue 121 type sequence F description binding site for residue PLC B 404 source : AC9 29) chain B residue 194 type sequence Y description binding site for residue PLC B 404 source : AC9 30) chain B residue 254 type sequence Y description binding site for residue PLC B 404 source : AC9 31) chain B residue 307 type sequence N description binding site for residue PLC B 404 source : AC9 32) chain B residue 42 type sequence F description binding site for residue ACT B 405 source : AD1 33) chain B residue 105 type sequence R description binding site for residue ACT B 405 source : AD1 34) chain C residue 77 type sequence R description binding site for residue ACT B 405 source : AD1 35) chain C residue 131 type sequence I description binding site for residue ACT B 405 source : AD1 36) chain C residue 181 type sequence E description binding site for residue ACT B 405 source : AD1 37) chain B residue 119 type sequence Y description binding site for residue PFL B 407 source : AD2 38) chain B residue 120 type sequence P description binding site for residue PFL B 407 source : AD2 39) chain B residue 197 type sequence Y description binding site for residue PFL B 407 source : AD2 40) chain B residue 201 type sequence I description binding site for residue PFL B 407 source : AD2 41) chain B residue 202 type sequence I description binding site for residue PFL B 407 source : AD2 42) chain B residue 205 type sequence M description binding site for residue PFL B 407 source : AD2 43) chain B residue 255 type sequence T description binding site for residue PFL B 407 source : AD2 44) chain B residue 258 type sequence I description binding site for residue PFL B 407 source : AD2 45) chain C residue 73 type sequence I description binding site for residue ACT C 401 source : AD3 46) chain C residue 74 type sequence P description binding site for residue ACT C 401 source : AD3 47) chain C residue 76 type sequence I description binding site for residue ACT C 401 source : AD3 48) chain C residue 85 type sequence R description binding site for residue ACT C 401 source : AD3 49) chain C residue 102 type sequence Y description binding site for residue ACT C 401 source : AD3 50) chain C residue 78 type sequence F description binding site for residue CL C 402 source : AD4 51) chain C residue 68 type sequence P description binding site for residue NA C 403 source : AD5 52) chain C residue 71 type sequence I description binding site for residue NA C 403 source : AD5 53) chain C residue 118 type sequence R description binding site for residue PLC C 404 source : AD6 54) chain C residue 121 type sequence F description binding site for residue PLC C 404 source : AD6 55) chain C residue 194 type sequence Y description binding site for residue PLC C 404 source : AD6 56) chain C residue 254 type sequence Y description binding site for residue PLC C 404 source : AD6 57) chain C residue 307 type sequence N description binding site for residue PLC C 404 source : AD6 58) chain C residue 42 type sequence F description binding site for residue ACT C 405 source : AD7 59) chain C residue 105 type sequence R description binding site for residue ACT C 405 source : AD7 60) chain D residue 77 type sequence R description binding site for residue ACT C 405 source : AD7 61) chain D residue 131 type sequence I description binding site for residue ACT C 405 source : AD7 62) chain D residue 181 type sequence E description binding site for residue ACT C 405 source : AD7 63) chain D residue 74 type sequence P description binding site for residue ACT D 401 source : AD8 64) chain D residue 76 type sequence I description binding site for residue ACT D 401 source : AD8 65) chain D residue 85 type sequence R description binding site for residue ACT D 401 source : AD8 66) chain D residue 102 type sequence Y description binding site for residue ACT D 401 source : AD8 67) chain D residue 78 type sequence F description binding site for residue CL D 402 source : AD9 68) chain D residue 5 type sequence V description binding site for residue NA D 403 source : AE1 69) chain D residue 68 type sequence P description binding site for residue NA D 403 source : AE1 70) chain D residue 71 type sequence I description binding site for residue NA D 403 source : AE1 71) chain D residue 72 type sequence W description binding site for residue NA D 403 source : AE1 72) chain D residue 73 type sequence I description binding site for residue NA D 403 source : AE1 73) chain D residue 118 type sequence R description binding site for residue PLC D 404 source : AE2 74) chain D residue 121 type sequence F description binding site for residue PLC D 404 source : AE2 75) chain D residue 194 type sequence Y description binding site for residue PLC D 404 source : AE2 76) chain D residue 254 type sequence Y description binding site for residue PLC D 404 source : AE2 77) chain D residue 307 type sequence N description binding site for residue PLC D 404 source : AE2 78) chain D residue 42 type sequence F description binding site for residue ACT D 405 source : AE3 79) chain D residue 105 type sequence R description binding site for residue ACT D 405 source : AE3 80) chain E residue 77 type sequence R description binding site for residue ACT D 405 source : AE3 81) chain E residue 131 type sequence I description binding site for residue ACT D 405 source : AE3 82) chain E residue 181 type sequence E description binding site for residue ACT D 405 source : AE3 83) chain A residue 77 type sequence R description binding site for residue ACT E 401 source : AE4 84) chain A residue 131 type sequence I description binding site for residue ACT E 401 source : AE4 85) chain A residue 181 type sequence E description binding site for residue ACT E 401 source : AE4 86) chain E residue 42 type sequence F description binding site for residue ACT E 401 source : AE4 87) chain E residue 105 type sequence R description binding site for residue ACT E 401 source : AE4 88) chain E residue 74 type sequence P description binding site for residue ACT E 402 source : AE5 89) chain E residue 76 type sequence I description binding site for residue ACT E 402 source : AE5 90) chain E residue 85 type sequence R description binding site for residue ACT E 402 source : AE5 91) chain E residue 102 type sequence Y description binding site for residue ACT E 402 source : AE5 92) chain E residue 78 type sequence F description binding site for residue CL E 403 source : AE6 93) chain E residue 68 type sequence P description binding site for residue NA E 404 source : AE7 94) chain E residue 71 type sequence I description binding site for residue NA E 404 source : AE7 95) chain E residue 118 type sequence R description binding site for residue PLC E 405 source : AE8 96) chain E residue 121 type sequence F description binding site for residue PLC E 405 source : AE8 97) chain E residue 254 type sequence Y description binding site for residue PLC E 405 source : AE8 98) chain E residue 307 type sequence N description binding site for residue PLC E 405 source : AE8 99) chain E residue 315 type sequence F description binding site for residue PLC E 405 source : AE8 100) chain E residue 119 type sequence Y description binding site for residue PFL E 406 source : AE9 101) chain E residue 120 type sequence P description binding site for residue PFL E 406 source : AE9 102) chain E residue 197 type sequence Y description binding site for residue PFL E 406 source : AE9 103) chain E residue 201 type sequence I description binding site for residue PFL E 406 source : AE9 104) chain E residue 205 type sequence M description binding site for residue PFL E 406 source : AE9 105) chain E residue 255 type sequence T description binding site for residue PFL E 406 source : AE9 106) chain E residue 258 type sequence I description binding site for residue PFL E 406 source : AE9 107) chain E residue 259 type sequence I description binding site for residue PFL E 406 source : AE9 108) chain A residue 194-216 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 109) chain A residue 220-244 type TRANSMEM sequence SYEANVTLVVSTLIAHIAANILVET description Helical source Swiss-Prot : SWS_FT_FI2 110) chain A residue 253-281 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 111) chain B residue 194-216 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 112) chain B residue 220-244 type TRANSMEM sequence SYEANVTLVVSTLIAHIAANILVET description Helical source Swiss-Prot : SWS_FT_FI2 113) chain B residue 253-281 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 114) chain C residue 194-216 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 115) chain C residue 220-244 type TRANSMEM sequence SYEANVTLVVSTLIAHIAANILVET description Helical source Swiss-Prot : SWS_FT_FI2 116) chain C residue 253-281 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 117) chain D residue 194-216 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 118) chain D residue 220-244 type TRANSMEM sequence SYEANVTLVVSTLIAHIAANILVET description Helical source Swiss-Prot : SWS_FT_FI2 119) chain D residue 253-281 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 120) chain E residue 194-216 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 121) chain E residue 220-244 type TRANSMEM sequence SYEANVTLVVSTLIAHIAANILVET description Helical source Swiss-Prot : SWS_FT_FI2 122) chain E residue 253-281 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 123) chain A residue 245-252 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 124) chain B residue 245-252 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 125) chain C residue 245-252 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 126) chain D residue 245-252 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 127) chain E residue 245-252 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 128) chain A residue 217-219 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 129) chain A residue 282-284 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 130) chain B residue 217-219 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 131) chain B residue 282-284 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 132) chain C residue 217-219 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 133) chain C residue 282-284 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 134) chain D residue 217-219 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 135) chain D residue 282-284 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 136) chain E residue 217-219 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 137) chain E residue 282-284 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3

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