eF-site ID 5mur-A PDB Code 5mur Chain A click to enlarge Title X-ray structure of the F14'A mutant of GLIC in complex with propofol Classification TRANSPORT PROTEIN Compound Proton-gated ion channel Source (GLIC_GLOVI) Sequence A:  VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLS LSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENA RDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQ TLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIES FTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAANILVET NLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQ PARAASITRASRIAFPVVFLLANIILAFLFF Description Functional site 1) chain A residue 74 type sequence P description binding site for residue ACT A 401 source : AC1 2) chain A residue 76 type sequence I description binding site for residue ACT A 401 source : AC1 3) chain A residue 85 type sequence R description binding site for residue ACT A 401 source : AC1 4) chain A residue 102 type sequence Y description binding site for residue ACT A 401 source : AC1 5) chain A residue 78 type sequence F description binding site for residue CL A 402 source : AC2 6) chain A residue 85 type sequence R description binding site for residue CL A 402 source : AC2 7) chain A residue 68 type sequence P description binding site for residue NA A 403 source : AC3 8) chain A residue 71 type sequence I description binding site for residue NA A 403 source : AC3 9) chain A residue 118 type sequence R description binding site for residue PLC A 404 source : AC4 10) chain A residue 121 type sequence F description binding site for residue PLC A 404 source : AC4 11) chain A residue 194 type sequence Y description binding site for residue PLC A 404 source : AC4 12) chain A residue 254 type sequence Y description binding site for residue PLC A 404 source : AC4 13) chain A residue 307 type sequence N description binding site for residue PLC A 404 source : AC4 14) chain A residue 42 type sequence F description binding site for residue ACT A 405 source : AC5 15) chain A residue 105 type sequence R description binding site for residue ACT A 405 source : AC5 16) chain A residue 77 type sequence R description binding site for residue ACT E 401 source : AE4 17) chain A residue 131 type sequence I description binding site for residue ACT E 401 source : AE4 18) chain A residue 181 type sequence E description binding site for residue ACT E 401 source : AE4 19) chain A residue 194-216 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 20) chain A residue 220-244 type TRANSMEM sequence SYEANVTLVVSTLIAHIAANILVET description Helical source Swiss-Prot : SWS_FT_FI2 21) chain A residue 253-281 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 22) chain A residue 245-252 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 217-219 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 282-284 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3

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