eF-site ID 5mnj-ABCDEFGH PDB Code 5mnj Chain A, B, C, D, E, F, G, H click to enlarge Title Structure of MDM2-MDMX-UbcH5B-ubiquitin complex Classification LIGASE Compound Ubiquitin-conjugating enzyme E2 D2 Source (MDM4_HUMAN) Sequence A:  ALKRIHKELNDLARDPPAQCRAGPVGDDMFHWQATIMGPN DSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSN GSIKLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVP EIARIYKTDREKYNRIAREWTQKYAM B:  QIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQ RLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG C:  SLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKL KKRNKPCPVCRQPIQMIVLTYFP D:  EDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRL KKAGASCPICKKEIQLVIKVFIA E:  ALKRIHKELNDLARDPPAQCRAGPVGDDMFHWQATIMGPN DSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSN GSIKLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVP EIARIYKTDREKYNRIAREWTQKYAM F:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG G:  SSSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAK KLKKRNKPCPVCRQPIQMIVLTYFP H:  MEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARR LKKAGASCPICKKEIQLVIKVFIA Description Functional site 1) chain C residue 438 type sequence C description binding site for residue ZN C 501 source : AC1 2) chain C residue 441 type sequence C description binding site for residue ZN C 501 source : AC1 3) chain C residue 461 type sequence C description binding site for residue ZN C 501 source : AC1 4) chain C residue 464 type sequence C description binding site for residue ZN C 501 source : AC1 5) chain C residue 452 type sequence H description binding site for residue ZN C 502 source : AC2 6) chain C residue 457 type sequence H description binding site for residue ZN C 502 source : AC2 7) chain C residue 475 type sequence C description binding site for residue ZN C 502 source : AC2 8) chain C residue 478 type sequence C description binding site for residue ZN C 502 source : AC2 9) chain D residue 437 type sequence C description binding site for residue ZN D 501 source : AC3 10) chain D residue 440 type sequence C description binding site for residue ZN D 501 source : AC3 11) chain D residue 460 type sequence C description binding site for residue ZN D 501 source : AC3 12) chain D residue 463 type sequence C description binding site for residue ZN D 501 source : AC3 13) chain D residue 451 type sequence H description binding site for residue ZN D 502 source : AC4 14) chain D residue 456 type sequence H description binding site for residue ZN D 502 source : AC4 15) chain D residue 474 type sequence C description binding site for residue ZN D 502 source : AC4 16) chain D residue 477 type sequence C description binding site for residue ZN D 502 source : AC4 17) chain D residue 472 type sequence A description binding site for residue SO4 D 503 source : AC5 18) chain D residue 473 type sequence S description binding site for residue SO4 D 503 source : AC5 19) chain D residue 478 type sequence K description binding site for residue SO4 D 503 source : AC5 20) chain E residue 139 type sequence R description binding site for residue SO4 D 503 source : AC5 21) chain H residue 472 type sequence A description binding site for residue SO4 D 503 source : AC5 22) chain H residue 473 type sequence S description binding site for residue SO4 D 503 source : AC5 23) chain H residue 478 type sequence K description binding site for residue SO4 D 503 source : AC5 24) chain G residue 438 type sequence C description binding site for residue ZN G 501 source : AC6 25) chain G residue 441 type sequence C description binding site for residue ZN G 501 source : AC6 26) chain G residue 461 type sequence C description binding site for residue ZN G 501 source : AC6 27) chain G residue 464 type sequence C description binding site for residue ZN G 501 source : AC6 28) chain G residue 452 type sequence H description binding site for residue ZN G 502 source : AC7 29) chain G residue 457 type sequence H description binding site for residue ZN G 502 source : AC7 30) chain G residue 475 type sequence C description binding site for residue ZN G 502 source : AC7 31) chain G residue 478 type sequence C description binding site for residue ZN G 502 source : AC7 32) chain H residue 451 type sequence H description binding site for residue ZN H 501 source : AC8 33) chain H residue 456 type sequence H description binding site for residue ZN H 501 source : AC8 34) chain H residue 474 type sequence C description binding site for residue ZN H 501 source : AC8 35) chain H residue 477 type sequence C description binding site for residue ZN H 501 source : AC8 36) chain H residue 437 type sequence C description binding site for residue ZN H 502 source : AC9 37) chain H residue 440 type sequence C description binding site for residue ZN H 502 source : AC9 38) chain H residue 460 type sequence C description binding site for residue ZN H 502 source : AC9 39) chain H residue 463 type sequence C description binding site for residue ZN H 502 source : AC9 40) chain D residue 442 type sequence K description binding site for residue SO4 H 503 source : AD1 41) chain D residue 443 type sequence R description binding site for residue SO4 H 503 source : AD1 42) chain D residue 466 type sequence R description binding site for residue SO4 H 503 source : AD1 43) chain H residue 442 type sequence K description binding site for residue SO4 H 503 source : AD1 44) chain H residue 443 type sequence R description binding site for residue SO4 H 503 source : AD1 45) chain H residue 466 type sequence R description binding site for residue SO4 H 503 source : AD1 46) chain E residue 75 type sequence H description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 47) chain E residue 77 type sequence N description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 48) chain E residue 78 type sequence I description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 49) chain E residue 84 type sequence I description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 50) chain E residue 86 type sequence L description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 51) chain E residue 117 type sequence D description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 52) chain E residue 119 type sequence L description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 53) chain E residue 120 type sequence V description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 54) chain E residue 134 type sequence Y description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 55) chain F residue 75 type sequence G description binding site for Di-peptide GLY F 76 and LYS E 85 source : AD2 56) chain C residue 429 type MOD_RES sequence S description Phosphoserine; by ATM => ECO:0000269|PubMed:19816404 source Swiss-Prot : SWS_FT_FI2 57) chain G residue 429 type MOD_RES sequence S description Phosphoserine; by ATM => ECO:0000269|PubMed:19816404 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 59) chain D residue 437-478 type ZN_FING sequence CSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPI CK description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 60) chain H residue 437-478 type ZN_FING sequence CSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPI CK description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1

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