eF-site ID 5mkx-AB PDB Code 5mkx Chain A, B click to enlarge Title 1.68A STRUCTURE PCAF BROMODOMAIN WITH 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one Classification TRANSCRIPTION Compound Histone acetyltransferase KAT2B Source Homo sapiens (Human) (KAT2B_HUMAN) Sequence A:  DQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIR FPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPP ESEYYKCANILEKFFFSKIKEAGLID B:  PDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVI RFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNP PESEYYKCANILEKFFFSKIKEAGLID Description Functional site 1) chain A residue 747 type sequence P description binding site for residue 82I A 901 source : AC1 2) chain A residue 752 type sequence V description binding site for residue 82I A 901 source : AC1 3) chain A residue 756 type sequence E description binding site for residue 82I A 901 source : AC1 4) chain A residue 802 type sequence Y description binding site for residue 82I A 901 source : AC1 5) chain A residue 803 type sequence N description binding site for residue 82I A 901 source : AC1 6) chain A residue 809 type sequence Y description binding site for residue 82I A 901 source : AC1 7) chain A residue 776 type sequence R description binding site for residue SO4 A 902 source : AC2 8) chain B residue 729 type sequence Y description binding site for residue SO4 A 902 source : AC2 9) chain B residue 780 type sequence R description binding site for residue SO4 A 902 source : AC2 10) chain A residue 751 type sequence P description binding site for residue EPE A 903 source : AC3 11) chain A residue 754 type sequence R description binding site for residue EPE A 903 source : AC3 12) chain A residue 761 type sequence Y description binding site for residue EPE A 903 source : AC3 13) chain B residue 747 type sequence P description binding site for residue 82I B 901 source : AC4 14) chain B residue 748 type sequence F description binding site for residue 82I B 901 source : AC4 15) chain B residue 802 type sequence Y description binding site for residue 82I B 901 source : AC4 16) chain B residue 803 type sequence N description binding site for residue 82I B 901 source : AC4 17) chain B residue 809 type sequence Y description binding site for residue 82I B 901 source : AC4 18) chain B residue 766 type sequence F description binding site for residue BU1 B 902 source : AC5 19) chain A residue 745-802 type prosite sequence AWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVS KKLFMADLQRVFTNCKEY description BROMODOMAIN_1 Bromodomain signature. AwpFmepvKrteap..GYYevIrfpMdlktMserlknry..Yvskklfmadlqr.VftNCkeY source prosite : PS00633

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