eF-site ID 5maf-A PDB Code 5maf Chain A click to enlarge Title Crystal structure of MELK in complex with an inhibitor Classification TRANSFERASE Compound Maternal embryonic leucine zipper kinase Source Homo sapiens (Human) (MELK_HUMAN) Sequence A:  PKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIK IMDKNTLDLPRIKTEIEALKNLRHQHICQLYHVLETANKI FMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAY VHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKSLAYAA PELIQGKLGSEADVWSMGILLYVLMCGFLPFDDDNVMALY KKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLL NHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNR QTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR Description (1)  Maternal embryonic leucine zipper kinase (E.C.2.7.11.1,2.7.10.2) Functional site 1) chain A residue 35 type sequence E description binding site for residue DMS A 401 source : AC1 2) chain A residue 36 type sequence M description binding site for residue DMS A 401 source : AC1 3) chain A residue 73 type sequence Y description binding site for residue DMS A 401 source : AC1 4) chain A residue 88 type sequence Y description binding site for residue DMS A 401 source : AC1 5) chain A residue 142 type sequence E description binding site for residue DMS A 401 source : AC1 6) chain A residue 326 type sequence R description binding site for residue DMS A 401 source : AC1 7) chain A residue 114 type sequence R description binding site for residue CL A 402 source : AC2 8) chain A residue 272 type sequence E description binding site for residue CL A 402 source : AC2 9) chain A residue 2 type sequence K description binding site for residue XIN A 403 source : AC3 10) chain A residue 15 type sequence E description binding site for residue XIN A 403 source : AC3 11) chain A residue 17 type sequence I description binding site for residue XIN A 403 source : AC3 12) chain A residue 18 type sequence G description binding site for residue XIN A 403 source : AC3 13) chain A residue 25 type sequence V description binding site for residue XIN A 403 source : AC3 14) chain A residue 38 type sequence A description binding site for residue XIN A 403 source : AC3 15) chain A residue 40 type sequence K description binding site for residue XIN A 403 source : AC3 16) chain A residue 57 type sequence E description binding site for residue XIN A 403 source : AC3 17) chain A residue 86 type sequence L description binding site for residue XIN A 403 source : AC3 18) chain A residue 87 type sequence E description binding site for residue XIN A 403 source : AC3 19) chain A residue 88 type sequence Y description binding site for residue XIN A 403 source : AC3 20) chain A residue 89 type sequence C description binding site for residue XIN A 403 source : AC3 21) chain A residue 92 type sequence G description binding site for residue XIN A 403 source : AC3 22) chain A residue 93 type sequence E description binding site for residue XIN A 403 source : AC3 23) chain A residue 139 type sequence L description binding site for residue XIN A 403 source : AC3 24) chain A residue 149 type sequence I description binding site for residue XIN A 403 source : AC3 25) chain A residue 150 type sequence D description binding site for residue XIN A 403 source : AC3 26) chain A residue 132 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 17 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 40 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 56 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:16216881 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 17-40 type prosite sequence IGTGGFAKVKLACHILTGEMVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGTGGFAKVKlAchiltgem..........VAIK source prosite : PS00107 31) chain A residue 128-140 type prosite sequence YAHRDLKPENLLF description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. YaHrDLKpeNLLF source prosite : PS00108 32) chain A residue 171 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000269|PubMed:16216881 source Swiss-Prot : SWS_FT_FI6 33) chain A residue 253 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000269|PubMed:16216881 source Swiss-Prot : SWS_FT_FI6

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