eF-site ID 5m7f-AB PDB Code 5m7f Chain A, B click to enlarge Title Human porphobilinogen deaminase in complex with DPM cofactor Classification TRANSFERASE Compound Porphobilinogen deaminase Source (HEM3_HUMAN) Sequence A:  VIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSSL FTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKR ENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQR KFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRM GWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVG VLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQL YLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLV GITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDV B:  VIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSLF TKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRE NPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRK FPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMG WHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGV LHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLY LTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVG ITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDV Description Functional site 1) chain A residue 96 type sequence S description binding site for residue DPM A 401 source : AC1 2) chain A residue 98 type sequence K description binding site for residue DPM A 401 source : AC1 3) chain A residue 99 type sequence D description binding site for residue DPM A 401 source : AC1 4) chain A residue 146 type sequence S description binding site for residue DPM A 401 source : AC1 5) chain A residue 147 type sequence S description binding site for residue DPM A 401 source : AC1 6) chain A residue 149 type sequence R description binding site for residue DPM A 401 source : AC1 7) chain A residue 150 type sequence R description binding site for residue DPM A 401 source : AC1 8) chain A residue 173 type sequence R description binding site for residue DPM A 401 source : AC1 9) chain A residue 189 type sequence A description binding site for residue DPM A 401 source : AC1 10) chain A residue 195 type sequence R description binding site for residue DPM A 401 source : AC1 11) chain A residue 217 type sequence Q description binding site for residue DPM A 401 source : AC1 12) chain A residue 218 type sequence G description binding site for residue DPM A 401 source : AC1 13) chain A residue 261 type sequence C description binding site for residue DPM A 401 source : AC1 14) chain A residue 300 type sequence H description binding site for residue SO4 A 402 source : AC2 15) chain A residue 302 type sequence P description binding site for residue SO4 A 402 source : AC2 16) chain A residue 303 type sequence A description binding site for residue SO4 A 402 source : AC2 17) chain A residue 304 type sequence Q description binding site for residue SO4 A 402 source : AC2 18) chain A residue 119 type sequence P description binding site for residue SO4 A 403 source : AC3 19) chain A residue 246 type sequence R description binding site for residue SO4 A 403 source : AC3 20) chain A residue 299 type sequence I description binding site for residue SO4 A 404 source : AC4 21) chain A residue 300 type sequence H description binding site for residue SO4 A 404 source : AC4 22) chain A residue 327 type sequence P description binding site for residue SO4 A 404 source : AC4 23) chain B residue 300 type sequence H description binding site for residue SO4 B 402 source : AC5 24) chain B residue 302 type sequence P description binding site for residue SO4 B 402 source : AC5 25) chain B residue 303 type sequence A description binding site for residue SO4 B 402 source : AC5 26) chain B residue 304 type sequence Q description binding site for residue SO4 B 402 source : AC5 27) chain B residue 119 type sequence P description binding site for residue SO4 B 403 source : AC6 28) chain B residue 120 type sequence H description binding site for residue SO4 B 403 source : AC6 29) chain B residue 246 type sequence R description binding site for residue SO4 B 403 source : AC6 30) chain B residue 29 type sequence Q description binding site for residue SO4 B 404 source : AC7 31) chain B residue 169 type sequence N description binding site for residue SO4 B 404 source : AC7 32) chain B residue 96 type sequence S description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 33) chain B residue 98 type sequence K description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 34) chain B residue 99 type sequence D description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 35) chain B residue 145 type sequence T description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 36) chain B residue 146 type sequence S description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 37) chain B residue 147 type sequence S description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 38) chain B residue 149 type sequence R description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 39) chain B residue 150 type sequence R description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 40) chain B residue 173 type sequence R description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 41) chain B residue 188 type sequence L description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 42) chain B residue 189 type sequence A description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 43) chain B residue 195 type sequence R description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 44) chain B residue 217 type sequence Q description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 45) chain B residue 218 type sequence G description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 46) chain B residue 260 type sequence G description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 47) chain B residue 262 type sequence S description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 48) chain B residue 263 type sequence V description binding site for Di-peptide DPM B 401 and CYS B 261 source : AC8 49) chain A residue 250-266 type prosite sequence ERAFLRHLEGGCSVPVA description PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA source prosite : PS00533 50) chain A residue 32 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 86 type MOD_RES sequence E description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 164 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 53) chain B residue 32 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 86 type MOD_RES sequence E description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 164 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 91 type MOD_RES sequence D description N6-acetyllysine => ECO:0000250|UniProtKB:P22907 source Swiss-Prot : SWS_FT_FI3 57) chain B residue 91 type MOD_RES sequence D description N6-acetyllysine => ECO:0000250|UniProtKB:P22907 source Swiss-Prot : SWS_FT_FI3 58) chain A residue 278 type MOD_RES sequence L description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296 source Swiss-Prot : SWS_FT_FI4 59) chain B residue 278 type MOD_RES sequence L description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296 source Swiss-Prot : SWS_FT_FI4

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