eF-site ID 5m7f-A PDB Code 5m7f Chain A click to enlarge Title Human porphobilinogen deaminase in complex with DPM cofactor Classification TRANSFERASE Compound Porphobilinogen deaminase Source (HEM3_HUMAN) Sequence A:  VIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSSL FTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKR ENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQR KFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRM GWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVG VLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQL YLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLV GITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDV Description Functional site 1) chain A residue 96 type sequence S description binding site for residue DPM A 401 source : AC1 2) chain A residue 98 type sequence K description binding site for residue DPM A 401 source : AC1 3) chain A residue 99 type sequence D description binding site for residue DPM A 401 source : AC1 4) chain A residue 146 type sequence S description binding site for residue DPM A 401 source : AC1 5) chain A residue 147 type sequence S description binding site for residue DPM A 401 source : AC1 6) chain A residue 149 type sequence R description binding site for residue DPM A 401 source : AC1 7) chain A residue 150 type sequence R description binding site for residue DPM A 401 source : AC1 8) chain A residue 173 type sequence R description binding site for residue DPM A 401 source : AC1 9) chain A residue 189 type sequence A description binding site for residue DPM A 401 source : AC1 10) chain A residue 195 type sequence R description binding site for residue DPM A 401 source : AC1 11) chain A residue 217 type sequence Q description binding site for residue DPM A 401 source : AC1 12) chain A residue 218 type sequence G description binding site for residue DPM A 401 source : AC1 13) chain A residue 261 type sequence C description binding site for residue DPM A 401 source : AC1 14) chain A residue 300 type sequence H description binding site for residue SO4 A 402 source : AC2 15) chain A residue 302 type sequence P description binding site for residue SO4 A 402 source : AC2 16) chain A residue 303 type sequence A description binding site for residue SO4 A 402 source : AC2 17) chain A residue 304 type sequence Q description binding site for residue SO4 A 402 source : AC2 18) chain A residue 119 type sequence P description binding site for residue SO4 A 403 source : AC3 19) chain A residue 246 type sequence R description binding site for residue SO4 A 403 source : AC3 20) chain A residue 299 type sequence I description binding site for residue SO4 A 404 source : AC4 21) chain A residue 300 type sequence H description binding site for residue SO4 A 404 source : AC4 22) chain A residue 327 type sequence P description binding site for residue SO4 A 404 source : AC4 23) chain A residue 278 type MOD_RES sequence L description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 250-266 type prosite sequence ERAFLRHLEGGCSVPVA description PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA source prosite : PS00533 25) chain A residue 32 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 86 type MOD_RES sequence E description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 164 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 91 type MOD_RES sequence D description N6-acetyllysine => ECO:0000250|UniProtKB:P22907 source Swiss-Prot : SWS_FT_FI3

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