eF-site ID 5lwe-B PDB Code 5lwe Chain B click to enlarge Title Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon Classification MEMBRANE PROTEIN Compound C-C chemokine receptor type 9 Source (CCR9_HUMAN) Sequence B:  NFEDFYCEKNNVRQFASHFLPPLYWLVFIVGALGNSLVIL VYWYCARAKTATDMFLLNLAIADLLFLVTLPFWAIAAATF MCKVVNSMYKMNFYSCVLLIMCICVDRYIAIAQAMRAHTW REKRLLYSKMVCFTIWVLAAALCIPEILTKLKSAVLALKV ILGFFLPFVVMACCYTIIIHTLIQAKKSSKHKALKATITV LTVFVLSQFPYNCILLVQTIDAYAMFISNCAVSTAIDICF QVTQAIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGAIS QAAAH Description Functional site 1) chain B residue 239 type sequence H description binding site for residue OLA A 404 source : AC4 2) chain B residue 53 type sequence P description binding site for residue OLA A 407 source : AC7 3) chain B residue 167 type sequence M description binding site for residue OLA A 411 source : AD1 4) chain B residue 181 type sequence I description binding site for residue OLA A 413 source : AD3 5) chain B residue 37 type sequence Y description binding site for residue OLA A 414 source : AD4 6) chain B residue 325 type sequence R description binding site for residue OLA A 416 source : AD6 7) chain B residue 69 type sequence V description binding site for residue 79K B 401 source : AD9 8) chain B residue 78 type sequence R description binding site for residue 79K B 401 source : AD9 9) chain B residue 81 type sequence T description binding site for residue 79K B 401 source : AD9 10) chain B residue 83 type sequence T description binding site for residue 79K B 401 source : AD9 11) chain B residue 84 type sequence D description binding site for residue 79K B 401 source : AD9 12) chain B residue 87 type sequence L description binding site for residue 79K B 401 source : AD9 13) chain B residue 144 type sequence R description binding site for residue 79K B 401 source : AD9 14) chain B residue 252 type sequence A description binding site for residue 79K B 401 source : AD9 15) chain B residue 255 type sequence A description binding site for residue 79K B 401 source : AD9 16) chain B residue 256 type sequence T description binding site for residue 79K B 401 source : AD9 17) chain B residue 259 type sequence V description binding site for residue 79K B 401 source : AD9 18) chain B residue 317 type sequence Y description binding site for residue 79K B 401 source : AD9 19) chain B residue 321 type sequence G description binding site for residue 79K B 401 source : AD9 20) chain B residue 322 type sequence E description binding site for residue 79K B 401 source : AD9 21) chain B residue 323 type sequence R description binding site for residue 79K B 401 source : AD9 22) chain B residue 324 type sequence F description binding site for residue 79K B 401 source : AD9 23) chain B residue 327 type sequence D description binding site for residue 79K B 401 source : AD9 24) chain B residue 254 type sequence K description binding site for residue OLA B 402 source : AE1 25) chain B residue 250 type sequence H description binding site for residue OLA B 403 source : AE2 26) chain B residue 254 type sequence K description binding site for residue OLA B 403 source : AE2 27) chain B residue 258 type sequence T description binding site for residue OLA B 403 source : AE2 28) chain B residue 261 type sequence T description binding site for residue OLA B 403 source : AE2 29) chain B residue 262 type sequence V description binding site for residue OLA B 403 source : AE2 30) chain B residue 265 type sequence L description binding site for residue OLA B 403 source : AE2 31) chain B residue 266 type sequence S description binding site for residue OLA B 403 source : AE2 32) chain B residue 234 type sequence Y description binding site for residue OLA B 404 source : AE3 33) chain B residue 250 type sequence H description binding site for residue OLA B 404 source : AE3 34) chain B residue 257 type sequence I description binding site for residue OLA B 404 source : AE3 35) chain B residue 250 type sequence H description binding site for residue OLA B 405 source : AE4 36) chain B residue 86 type sequence F description binding site for residue OLA B 406 source : AE5 37) chain B residue 138 type sequence M description binding site for residue OLA B 406 source : AE5 38) chain B residue 143 type sequence D description binding site for residue OLA B 406 source : AE5 39) chain B residue 146 type sequence I description binding site for residue OLA B 406 source : AE5 40) chain B residue 161 type sequence R description binding site for residue OLA B 406 source : AE5 41) chain B residue 175 type sequence L description binding site for residue OLA B 406 source : AE5 42) chain B residue 145 type sequence Y description binding site for residue OLA B 407 source : AE6 43) chain B residue 227 type sequence F description binding site for residue OLA B 407 source : AE6 44) chain B residue 235 type sequence T description binding site for residue OLA B 407 source : AE6 45) chain B residue 170 type sequence F description binding site for residue OLA B 408 source : AE7 46) chain B residue 74 type sequence W description binding site for residue OLA B 409 source : AE8 47) chain B residue 85 type sequence M description binding site for residue OLA B 409 source : AE8 48) chain B residue 89 type sequence N description binding site for residue OLA B 409 source : AE8 49) chain B residue 92 type sequence I description binding site for residue OLA B 410 source : AE9 50) chain B residue 67 type sequence S description binding site for residue OLA B 411 source : AF1 51) chain B residue 279 type sequence I description binding site for residue OLA B 414 source : AF3 52) chain B residue 283 type sequence A description binding site for residue OLA B 414 source : AF3 53) chain B residue 285 type sequence F description binding site for residue OLA B 414 source : AF3 54) chain B residue 291 type sequence V description binding site for residue OLA B 414 source : AF3 55) chain B residue 144 type sequence R description binding site for residue MLI B 415 source : AF4 56) chain B residue 147 type sequence A description binding site for residue MLI B 415 source : AF4 57) chain B residue 161 type sequence R description binding site for residue MLI B 415 source : AF4 58) chain B residue 64 type sequence L description binding site for residues OLA A 410 and OLA B 412 source : AF5 59) chain B residue 92 type sequence I description binding site for residues OLA A 410 and OLA B 412 source : AF5 60) chain B residue 49-74 type TRANSMEM sequence HFLPPLYWLVFIVGALGNSLVILVYW description Helical; Name=1 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI1 61) chain B residue 32 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI10 62) chain B residue 75-85 type TOPO_DOM sequence YCARAKTATDM description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 63) chain B residue 151-159 type TOPO_DOM sequence AMRAHTWRE description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 64) chain B residue 244-248 type TOPO_DOM sequence AKKSS description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 65) chain B residue 86-109 type TRANSMEM sequence FLLNLAIADLLFLVTLPFWAIAAA description Helical; Name=2 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI3 66) chain B residue 284-290 type TOPO_DOM sequence MFISNCA description Extracellular => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI4 67) chain B residue 121-150 type TRANSMEM sequence VVNSMYKMNFYSCVLLIMCICVDRYIAIAQ description Helical; Name=3 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI5 68) chain B residue 160-185 type TRANSMEM sequence KRLLYSKMVCFTIWVLAAALCIPEIL description Helical; Name=4 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI6 69) chain B residue 209-243 type TRANSMEM sequence KLKSAVLALKVILGFFLPFVVMACCYTIIIHTLIQ description Helical; Name=5 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI7 70) chain B residue 249-283 type TRANSMEM sequence KHKALKATITVLTVFVLSQFPYNCILLVQTIDAYA description Helical; Name=6 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI8 71) chain B residue 291-321 type TRANSMEM sequence VSTAIDICFQVTQAIAFFHSCLNPVLYVFVG description Helical; Name=7 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI9

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