eF-site ID 5lwe-AB PDB Code 5lwe Chain A, B click to enlarge Title Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon Classification MEMBRANE PROTEIN Compound C-C chemokine receptor type 9 Source (CCR9_HUMAN) Sequence A:  RQFASHFLPPLYWLVFIVGALGNSLVILVYWYCARAKTAT DMFLLNLAIADLLFLVTLPFWAIATFMCKVVNSMYKMNFY SCVLLIMCICVDRYIAIAQAMRAHTWREKRLLYSKMVCFT IWVLAAALCIPEILYCTTKLKSAVLALKVILGFFLPFVVM ACCYTIIIHTLIQAKKSSKHKALKATITVLTVFVLSQFPY NCILLVQTIDAYAMFISNCAVSTAIDICFQVTQAIAFFHS CLNPVLYVFVGERFRRDLVKTLKNLGAISQAAAHH B:  NFEDFYCEKNNVRQFASHFLPPLYWLVFIVGALGNSLVIL VYWYCARAKTATDMFLLNLAIADLLFLVTLPFWAIAAATF MCKVVNSMYKMNFYSCVLLIMCICVDRYIAIAQAMRAHTW REKRLLYSKMVCFTIWVLAAALCIPEILTKLKSAVLALKV ILGFFLPFVVMACCYTIIIHTLIQAKKSSKHKALKATITV LTVFVLSQFPYNCILLVQTIDAYAMFISNCAVSTAIDICF QVTQAIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGAIS QAAAH Description Functional site 1) chain A residue 69 type sequence V description binding site for residue 79K A 401 source : AC1 2) chain A residue 78 type sequence R description binding site for residue 79K A 401 source : AC1 3) chain A residue 81 type sequence T description binding site for residue 79K A 401 source : AC1 4) chain A residue 83 type sequence T description binding site for residue 79K A 401 source : AC1 5) chain A residue 84 type sequence D description binding site for residue 79K A 401 source : AC1 6) chain A residue 87 type sequence L description binding site for residue 79K A 401 source : AC1 7) chain A residue 144 type sequence R description binding site for residue 79K A 401 source : AC1 8) chain A residue 255 type sequence A description binding site for residue 79K A 401 source : AC1 9) chain A residue 256 type sequence T description binding site for residue 79K A 401 source : AC1 10) chain A residue 259 type sequence V description binding site for residue 79K A 401 source : AC1 11) chain A residue 317 type sequence Y description binding site for residue 79K A 401 source : AC1 12) chain A residue 321 type sequence G description binding site for residue 79K A 401 source : AC1 13) chain A residue 322 type sequence E description binding site for residue 79K A 401 source : AC1 14) chain A residue 323 type sequence R description binding site for residue 79K A 401 source : AC1 15) chain A residue 324 type sequence F description binding site for residue 79K A 401 source : AC1 16) chain A residue 327 type sequence D description binding site for residue 79K A 401 source : AC1 17) chain A residue 265 type sequence L description binding site for residue OLA A 402 source : AC2 18) chain A residue 250 type sequence H description binding site for residue OLA A 403 source : AC3 19) chain A residue 234 type sequence Y description binding site for residue OLA A 404 source : AC4 20) chain A residue 235 type sequence T description binding site for residue OLA A 404 source : AC4 21) chain A residue 238 type sequence I description binding site for residue OLA A 404 source : AC4 22) chain A residue 241 type sequence L description binding site for residue OLA A 404 source : AC4 23) chain B residue 239 type sequence H description binding site for residue OLA A 404 source : AC4 24) chain A residue 145 type sequence Y description binding site for residue OLA A 405 source : AC5 25) chain A residue 239 type sequence H description binding site for residue OLA A 405 source : AC5 26) chain A residue 74 type sequence W description binding site for residue OLA A 406 source : AC6 27) chain A residue 96 type sequence L description binding site for residue OLA A 406 source : AC6 28) chain A residue 56 type sequence W description binding site for residue OLA A 407 source : AC7 29) chain A residue 102 type sequence P description binding site for residue OLA A 407 source : AC7 30) chain A residue 106 type sequence I description binding site for residue OLA A 407 source : AC7 31) chain B residue 53 type sequence P description binding site for residue OLA A 407 source : AC7 32) chain A residue 96 type sequence L description binding site for residue OLA A 408 source : AC8 33) chain A residue 128 type sequence M description binding site for residue OLA A 408 source : AC8 34) chain A residue 173 type sequence W description binding site for residue OLA A 408 source : AC8 35) chain A residue 64 type sequence L description binding site for residue OLA A 409 source : AC9 36) chain A residue 164 type sequence Y description binding site for residue OLA A 411 source : AD1 37) chain A residue 167 type sequence M description binding site for residue OLA A 411 source : AD1 38) chain B residue 167 type sequence M description binding site for residue OLA A 411 source : AD1 39) chain A residue 319 type sequence F description binding site for residue OLA A 412 source : AD2 40) chain A residue 169 type sequence C description binding site for residue OLA A 413 source : AD3 41) chain A residue 170 type sequence F description binding site for residue OLA A 413 source : AD3 42) chain A residue 173 type sequence W description binding site for residue OLA A 413 source : AD3 43) chain A residue 177 type sequence A description binding site for residue OLA A 413 source : AD3 44) chain A residue 178 type sequence A description binding site for residue OLA A 413 source : AD3 45) chain A residue 181 type sequence I description binding site for residue OLA A 413 source : AD3 46) chain B residue 181 type sequence I description binding site for residue OLA A 413 source : AD3 47) chain A residue 143 type sequence D description binding site for residue OLA A 414 source : AD4 48) chain A residue 161 type sequence R description binding site for residue OLA A 414 source : AD4 49) chain B residue 37 type sequence Y description binding site for residue OLA A 414 source : AD4 50) chain A residue 70 type sequence I description binding site for residue OLA A 415 source : AD5 51) chain A residue 68 type sequence L description binding site for residue OLA A 416 source : AD6 52) chain A residue 328 type sequence L description binding site for residue OLA A 416 source : AD6 53) chain A residue 335 type sequence L description binding site for residue OLA A 416 source : AD6 54) chain A residue 336 type sequence G description binding site for residue OLA A 416 source : AD6 55) chain B residue 325 type sequence R description binding site for residue OLA A 416 source : AD6 56) chain A residue 308 type sequence F description binding site for residue CLR A 417 source : AD7 57) chain A residue 144 type sequence R description binding site for residue MLI A 418 source : AD8 58) chain A residue 147 type sequence A description binding site for residue MLI A 418 source : AD8 59) chain A residue 161 type sequence R description binding site for residue MLI A 418 source : AD8 60) chain A residue 323 type sequence R description binding site for residue MLI A 418 source : AD8 61) chain B residue 69 type sequence V description binding site for residue 79K B 401 source : AD9 62) chain B residue 78 type sequence R description binding site for residue 79K B 401 source : AD9 63) chain B residue 81 type sequence T description binding site for residue 79K B 401 source : AD9 64) chain B residue 83 type sequence T description binding site for residue 79K B 401 source : AD9 65) chain B residue 84 type sequence D description binding site for residue 79K B 401 source : AD9 66) chain B residue 87 type sequence L description binding site for residue 79K B 401 source : AD9 67) chain B residue 144 type sequence R description binding site for residue 79K B 401 source : AD9 68) chain B residue 252 type sequence A description binding site for residue 79K B 401 source : AD9 69) chain B residue 255 type sequence A description binding site for residue 79K B 401 source : AD9 70) chain B residue 256 type sequence T description binding site for residue 79K B 401 source : AD9 71) chain B residue 259 type sequence V description binding site for residue 79K B 401 source : AD9 72) chain B residue 317 type sequence Y description binding site for residue 79K B 401 source : AD9 73) chain B residue 321 type sequence G description binding site for residue 79K B 401 source : AD9 74) chain B residue 322 type sequence E description binding site for residue 79K B 401 source : AD9 75) chain B residue 323 type sequence R description binding site for residue 79K B 401 source : AD9 76) chain B residue 324 type sequence F description binding site for residue 79K B 401 source : AD9 77) chain B residue 327 type sequence D description binding site for residue 79K B 401 source : AD9 78) chain B residue 254 type sequence K description binding site for residue OLA B 402 source : AE1 79) chain B residue 250 type sequence H description binding site for residue OLA B 403 source : AE2 80) chain B residue 254 type sequence K description binding site for residue OLA B 403 source : AE2 81) chain B residue 258 type sequence T description binding site for residue OLA B 403 source : AE2 82) chain B residue 261 type sequence T description binding site for residue OLA B 403 source : AE2 83) chain B residue 262 type sequence V description binding site for residue OLA B 403 source : AE2 84) chain B residue 265 type sequence L description binding site for residue OLA B 403 source : AE2 85) chain B residue 266 type sequence S description binding site for residue OLA B 403 source : AE2 86) chain B residue 234 type sequence Y description binding site for residue OLA B 404 source : AE3 87) chain B residue 250 type sequence H description binding site for residue OLA B 404 source : AE3 88) chain B residue 257 type sequence I description binding site for residue OLA B 404 source : AE3 89) chain A residue 239 type sequence H description binding site for residue OLA B 405 source : AE4 90) chain B residue 250 type sequence H description binding site for residue OLA B 405 source : AE4 91) chain B residue 86 type sequence F description binding site for residue OLA B 406 source : AE5 92) chain B residue 138 type sequence M description binding site for residue OLA B 406 source : AE5 93) chain B residue 143 type sequence D description binding site for residue OLA B 406 source : AE5 94) chain B residue 146 type sequence I description binding site for residue OLA B 406 source : AE5 95) chain B residue 161 type sequence R description binding site for residue OLA B 406 source : AE5 96) chain B residue 175 type sequence L description binding site for residue OLA B 406 source : AE5 97) chain B residue 145 type sequence Y description binding site for residue OLA B 407 source : AE6 98) chain B residue 227 type sequence F description binding site for residue OLA B 407 source : AE6 99) chain B residue 235 type sequence T description binding site for residue OLA B 407 source : AE6 100) chain B residue 170 type sequence F description binding site for residue OLA B 408 source : AE7 101) chain B residue 74 type sequence W description binding site for residue OLA B 409 source : AE8 102) chain B residue 85 type sequence M description binding site for residue OLA B 409 source : AE8 103) chain B residue 89 type sequence N description binding site for residue OLA B 409 source : AE8 104) chain B residue 92 type sequence I description binding site for residue OLA B 410 source : AE9 105) chain B residue 67 type sequence S description binding site for residue OLA B 411 source : AF1 106) chain A residue 285 type sequence F description binding site for residue OLA B 414 source : AF3 107) chain B residue 279 type sequence I description binding site for residue OLA B 414 source : AF3 108) chain B residue 283 type sequence A description binding site for residue OLA B 414 source : AF3 109) chain B residue 285 type sequence F description binding site for residue OLA B 414 source : AF3 110) chain B residue 291 type sequence V description binding site for residue OLA B 414 source : AF3 111) chain B residue 144 type sequence R description binding site for residue MLI B 415 source : AF4 112) chain B residue 147 type sequence A description binding site for residue MLI B 415 source : AF4 113) chain B residue 161 type sequence R description binding site for residue MLI B 415 source : AF4 114) chain A residue 64 type sequence L description binding site for residues OLA A 410 and OLA B 412 source : AF5 115) chain A residue 319 type sequence F description binding site for residues OLA A 410 and OLA B 412 source : AF5 116) chain A residue 319 type sequence F description binding site for residues OLA A 410 and OLA B 412 source : AF5 117) chain A residue 339 type sequence S description binding site for residues OLA A 410 and OLA B 412 source : AF5 118) chain B residue 64 type sequence L description binding site for residues OLA A 410 and OLA B 412 source : AF5 119) chain B residue 92 type sequence I description binding site for residues OLA A 410 and OLA B 412 source : AF5 120) chain A residue 132-148 type prosite sequence SCVLLIMCICVDRYIAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SCVlLIMCICVDRYIaI source prosite : PS00237 121) chain A residue 49-74 type TRANSMEM sequence HFLPPLYWLVFIVGALGNSLVILVYW description Helical; Name=1 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI1 122) chain B residue 49-74 type TRANSMEM sequence HFLPPLYWLVFIVGALGNSLVILVYW description Helical; Name=1 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI1 123) chain A residue 75-85 type TOPO_DOM sequence YCARAKTATDM description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 124) chain A residue 151-159 type TOPO_DOM sequence AMRAHTWRE description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 125) chain A residue 244-248 type TOPO_DOM sequence AKKSS description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 126) chain B residue 75-85 type TOPO_DOM sequence YCARAKTATDM description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 127) chain B residue 151-159 type TOPO_DOM sequence AMRAHTWRE description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 128) chain B residue 244-248 type TOPO_DOM sequence AKKSS description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 129) chain B residue 86-109 type TRANSMEM sequence FLLNLAIADLLFLVTLPFWAIAAA description Helical; Name=2 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI3 130) chain A residue 186-208 type TOPO_DOM sequence YCTT description Extracellular => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI4 131) chain A residue 284-290 type TOPO_DOM sequence MFISNCA description Extracellular => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI4 132) chain B residue 284-290 type TOPO_DOM sequence MFISNCA description Extracellular => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI4 133) chain A residue 121-150 type TRANSMEM sequence VVNSMYKMNFYSCVLLIMCICVDRYIAIAQ description Helical; Name=3 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI5 134) chain B residue 121-150 type TRANSMEM sequence VVNSMYKMNFYSCVLLIMCICVDRYIAIAQ description Helical; Name=3 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI5 135) chain A residue 160-185 type TRANSMEM sequence KRLLYSKMVCFTIWVLAAALCIPEIL description Helical; Name=4 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI6 136) chain B residue 160-185 type TRANSMEM sequence KRLLYSKMVCFTIWVLAAALCIPEIL description Helical; Name=4 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI6 137) chain A residue 209-243 type TRANSMEM sequence KLKSAVLALKVILGFFLPFVVMACCYTIIIHTLIQ description Helical; Name=5 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI7 138) chain B residue 209-243 type TRANSMEM sequence KLKSAVLALKVILGFFLPFVVMACCYTIIIHTLIQ description Helical; Name=5 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI7 139) chain A residue 249-283 type TRANSMEM sequence KHKALKATITVLTVFVLSQFPYNCILLVQTIDAYA description Helical; Name=6 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI8 140) chain B residue 249-283 type TRANSMEM sequence KHKALKATITVLTVFVLSQFPYNCILLVQTIDAYA description Helical; Name=6 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI8 141) chain A residue 291-321 type TRANSMEM sequence VSTAIDICFQVTQAIAFFHSCLNPVLYVFVG description Helical; Name=7 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI9 142) chain B residue 291-321 type TRANSMEM sequence VSTAIDICFQVTQAIAFFHSCLNPVLYVFVG description Helical; Name=7 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI9 143) chain B residue 32 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI10

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