eF-site ID 5lwe-A PDB Code 5lwe Chain A click to enlarge Title Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon Classification MEMBRANE PROTEIN Compound C-C chemokine receptor type 9 Source (CCR9_HUMAN) Sequence A:  RQFASHFLPPLYWLVFIVGALGNSLVILVYWYCARAKTAT DMFLLNLAIADLLFLVTLPFWAIATFMCKVVNSMYKMNFY SCVLLIMCICVDRYIAIAQAMRAHTWREKRLLYSKMVCFT IWVLAAALCIPEILYCTTKLKSAVLALKVILGFFLPFVVM ACCYTIIIHTLIQAKKSSKHKALKATITVLTVFVLSQFPY NCILLVQTIDAYAMFISNCAVSTAIDICFQVTQAIAFFHS CLNPVLYVFVGERFRRDLVKTLKNLGAISQAAAHH Description Functional site 1) chain A residue 69 type sequence V description binding site for residue 79K A 401 source : AC1 2) chain A residue 78 type sequence R description binding site for residue 79K A 401 source : AC1 3) chain A residue 81 type sequence T description binding site for residue 79K A 401 source : AC1 4) chain A residue 83 type sequence T description binding site for residue 79K A 401 source : AC1 5) chain A residue 84 type sequence D description binding site for residue 79K A 401 source : AC1 6) chain A residue 87 type sequence L description binding site for residue 79K A 401 source : AC1 7) chain A residue 144 type sequence R description binding site for residue 79K A 401 source : AC1 8) chain A residue 255 type sequence A description binding site for residue 79K A 401 source : AC1 9) chain A residue 256 type sequence T description binding site for residue 79K A 401 source : AC1 10) chain A residue 259 type sequence V description binding site for residue 79K A 401 source : AC1 11) chain A residue 317 type sequence Y description binding site for residue 79K A 401 source : AC1 12) chain A residue 321 type sequence G description binding site for residue 79K A 401 source : AC1 13) chain A residue 322 type sequence E description binding site for residue 79K A 401 source : AC1 14) chain A residue 323 type sequence R description binding site for residue 79K A 401 source : AC1 15) chain A residue 324 type sequence F description binding site for residue 79K A 401 source : AC1 16) chain A residue 327 type sequence D description binding site for residue 79K A 401 source : AC1 17) chain A residue 265 type sequence L description binding site for residue OLA A 402 source : AC2 18) chain A residue 250 type sequence H description binding site for residue OLA A 403 source : AC3 19) chain A residue 234 type sequence Y description binding site for residue OLA A 404 source : AC4 20) chain A residue 235 type sequence T description binding site for residue OLA A 404 source : AC4 21) chain A residue 238 type sequence I description binding site for residue OLA A 404 source : AC4 22) chain A residue 241 type sequence L description binding site for residue OLA A 404 source : AC4 23) chain A residue 145 type sequence Y description binding site for residue OLA A 405 source : AC5 24) chain A residue 239 type sequence H description binding site for residue OLA A 405 source : AC5 25) chain A residue 74 type sequence W description binding site for residue OLA A 406 source : AC6 26) chain A residue 96 type sequence L description binding site for residue OLA A 406 source : AC6 27) chain A residue 56 type sequence W description binding site for residue OLA A 407 source : AC7 28) chain A residue 102 type sequence P description binding site for residue OLA A 407 source : AC7 29) chain A residue 106 type sequence I description binding site for residue OLA A 407 source : AC7 30) chain A residue 96 type sequence L description binding site for residue OLA A 408 source : AC8 31) chain A residue 128 type sequence M description binding site for residue OLA A 408 source : AC8 32) chain A residue 173 type sequence W description binding site for residue OLA A 408 source : AC8 33) chain A residue 64 type sequence L description binding site for residue OLA A 409 source : AC9 34) chain A residue 164 type sequence Y description binding site for residue OLA A 411 source : AD1 35) chain A residue 167 type sequence M description binding site for residue OLA A 411 source : AD1 36) chain A residue 319 type sequence F description binding site for residue OLA A 412 source : AD2 37) chain A residue 169 type sequence C description binding site for residue OLA A 413 source : AD3 38) chain A residue 170 type sequence F description binding site for residue OLA A 413 source : AD3 39) chain A residue 173 type sequence W description binding site for residue OLA A 413 source : AD3 40) chain A residue 177 type sequence A description binding site for residue OLA A 413 source : AD3 41) chain A residue 178 type sequence A description binding site for residue OLA A 413 source : AD3 42) chain A residue 181 type sequence I description binding site for residue OLA A 413 source : AD3 43) chain A residue 143 type sequence D description binding site for residue OLA A 414 source : AD4 44) chain A residue 161 type sequence R description binding site for residue OLA A 414 source : AD4 45) chain A residue 70 type sequence I description binding site for residue OLA A 415 source : AD5 46) chain A residue 68 type sequence L description binding site for residue OLA A 416 source : AD6 47) chain A residue 328 type sequence L description binding site for residue OLA A 416 source : AD6 48) chain A residue 335 type sequence L description binding site for residue OLA A 416 source : AD6 49) chain A residue 336 type sequence G description binding site for residue OLA A 416 source : AD6 50) chain A residue 308 type sequence F description binding site for residue CLR A 417 source : AD7 51) chain A residue 144 type sequence R description binding site for residue MLI A 418 source : AD8 52) chain A residue 147 type sequence A description binding site for residue MLI A 418 source : AD8 53) chain A residue 161 type sequence R description binding site for residue MLI A 418 source : AD8 54) chain A residue 323 type sequence R description binding site for residue MLI A 418 source : AD8 55) chain A residue 239 type sequence H description binding site for residue OLA B 405 source : AE4 56) chain A residue 285 type sequence F description binding site for residue OLA B 414 source : AF3 57) chain A residue 64 type sequence L description binding site for residues OLA A 410 and OLA B 412 source : AF5 58) chain A residue 319 type sequence F description binding site for residues OLA A 410 and OLA B 412 source : AF5 59) chain A residue 319 type sequence F description binding site for residues OLA A 410 and OLA B 412 source : AF5 60) chain A residue 339 type sequence S description binding site for residues OLA A 410 and OLA B 412 source : AF5 61) chain A residue 132-148 type prosite sequence SCVLLIMCICVDRYIAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SCVlLIMCICVDRYIaI source prosite : PS00237 62) chain A residue 49-74 type TRANSMEM sequence HFLPPLYWLVFIVGALGNSLVILVYW description Helical; Name=1 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 75-85 type TOPO_DOM sequence YCARAKTATDM description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 64) chain A residue 151-159 type TOPO_DOM sequence AMRAHTWRE description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 65) chain A residue 244-248 type TOPO_DOM sequence AKKSS description Cytoplasmic => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 186-208 type TOPO_DOM sequence YCTT description Extracellular => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI4 67) chain A residue 284-290 type TOPO_DOM sequence MFISNCA description Extracellular => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI4 68) chain A residue 121-150 type TRANSMEM sequence VVNSMYKMNFYSCVLLIMCICVDRYIAIAQ description Helical; Name=3 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI5 69) chain A residue 160-185 type TRANSMEM sequence KRLLYSKMVCFTIWVLAAALCIPEIL description Helical; Name=4 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI6 70) chain A residue 209-243 type TRANSMEM sequence KLKSAVLALKVILGFFLPFVVMACCYTIIIHTLIQ description Helical; Name=5 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI7 71) chain A residue 249-283 type TRANSMEM sequence KHKALKATITVLTVFVLSQFPYNCILLVQTIDAYA description Helical; Name=6 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI8 72) chain A residue 291-321 type TRANSMEM sequence VSTAIDICFQVTQAIAFFHSCLNPVLYVFVG description Helical; Name=7 => ECO:0000269|PubMed:27926729 source Swiss-Prot : SWS_FT_FI9

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