eF-site ID 5l9e-A
PDB Code 5l9e
Chain A

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Title CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
Classification Lyase/Inhibitor
Compound Carbonic anhydrase 2
Source (5L9E)
Sequence A:  SHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYD
PSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKG
GPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLV
HWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVD
VLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPP
LLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMV
DNWRPAQPLKNRQIKASFK
Description


Functional site
1) chain A
residue 94
type
sequence H
description binding site for residue ZN A 301
source : AC1
2) chain A
residue 96
type
sequence H
description binding site for residue ZN A 301
source : AC1
3) chain A
residue 119
type
sequence H
description binding site for residue ZN A 301
source : AC1
4) chain A
residue 4
type
sequence H
description binding site for residue ZN A 302
source : AC2
5) chain A
residue 64
type
sequence H
description binding site for residue ZN A 302
source : AC2
6) chain A
residue 17
type
sequence H
description binding site for residue ZN A 303
source : AC3
7) chain A
residue 174
type
sequence D
description binding site for residue ZN A 304
source : AC4
8) chain A
residue 34
type
sequence D
description binding site for residue ZN A 305
source : AC5
9) chain A
residue 36
type
sequence H
description binding site for residue ZN A 305
source : AC5
10) chain A
residue 186
type
sequence E
description binding site for residue ZN A 306
source : AC6
11) chain A
residue 52
type
sequence D
description binding site for residue ZN A 307
source : AC7
12) chain A
residue 15
type
sequence H
description binding site for residue ZN A 308
source : AC8
13) chain A
residue 62
type
sequence N
description binding site for residue GOL A 309
source : AC9
14) chain A
residue 65
type
sequence A
description binding site for residue GOL A 309
source : AC9
15) chain A
residue 67
type
sequence N
description binding site for residue GOL A 309
source : AC9
16) chain A
residue 92
type
sequence Q
description binding site for residue GOL A 309
source : AC9
17) chain A
residue 189
type
sequence D
description binding site for residue ZN A 310
source : AD1
18) chain A
residue 260
type
sequence K
description binding site for residue ZN A 310
source : AD1
19) chain A
residue 233
type
sequence E
description binding site for residue ZN A 311
source : AD2
20) chain A
residue 233
type
sequence E
description binding site for residue ZN A 311
source : AD2
21) chain A
residue 26
type
sequence E
description binding site for residue ZN C 303
source : AE2
22) chain A
residue 4
type
sequence H
description binding site for residues QUJ A 303 and QVE A 304
source : AF6
23) chain A
residue 169
type
sequence K
description binding site for residues QUJ A 303 and QVE A 304
source : AF6
24) chain A
residue 4
type
sequence H
description binding site for residues QVE A 304 and QUJ A 305
source : AF7
25) chain A
residue 19
type
sequence D
description binding site for residues QVE A 304 and QUJ A 305
source : AF7
26) chain A
residue 20
type
sequence F
description binding site for residues QVE A 304 and QUJ A 305
source : AF7
27) chain A
residue 169
type
sequence K
description binding site for residues QVE A 304 and QUJ A 305
source : AF7
28) chain A
residue 201
type
sequence P
description binding site for residues QVE A 304 and QUJ A 305
source : AF7
29) chain A
residue 4
type
sequence H
description binding site for residues QUJ A 305 and QVE A 306
source : AF8
30) chain A
residue 5
type
sequence W
description binding site for residues QUJ A 305 and QVE A 306
source : AF8
31) chain A
residue 19
type
sequence D
description binding site for residues QUJ A 305 and QVE A 306
source : AF8
32) chain A
residue 20
type
sequence F
description binding site for residues QUJ A 305 and QVE A 306
source : AF8
33) chain A
residue 64
type
sequence H
description binding site for residues QUJ A 305 and QVE A 306
source : AF8
34) chain A
residue 201
type
sequence P
description binding site for residues QUJ A 305 and QVE A 306
source : AF8
35) chain A
residue 64
type catalytic
sequence H
description 216
source MCSA : MCSA1
36) chain A
residue 94
type catalytic
sequence H
description 216
source MCSA : MCSA1
37) chain A
residue 96
type catalytic
sequence H
description 216
source MCSA : MCSA1
38) chain A
residue 106
type catalytic
sequence E
description 216
source MCSA : MCSA1
39) chain A
residue 119
type catalytic
sequence H
description 216
source MCSA : MCSA1
40) chain A
residue 198
type catalytic
sequence T
description 216
source MCSA : MCSA1
41) chain A
residue 105-121
type prosite
sequence SEHTVDKKKYAAELHLV
description ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdkkkYaaELHLV
source prosite : PS00162
42) chain A
residue 64
type ACT_SITE
sequence H
description Proton donor/acceptor => ECO:0000305|PubMed:15667203, ECO:0000305|PubMed:17330962
source Swiss-Prot : SWS_FT_FI1
43) chain A
residue 94
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:4621826, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942
source Swiss-Prot : SWS_FT_FI2
44) chain A
residue 96
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942
source Swiss-Prot : SWS_FT_FI3
45) chain A
residue 119
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942
source Swiss-Prot : SWS_FT_FI3
46) chain A
residue 198
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:19520834
source Swiss-Prot : SWS_FT_FI4
47) chain A
residue 7
type SITE
sequence Y
description Fine-tunes the proton-transfer properties of H-64 => ECO:0000305|PubMed:17330962
source Swiss-Prot : SWS_FT_FI5
48) chain A
residue 62
type SITE
sequence N
description Fine-tunes the proton-transfer properties of H-64; involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962
source Swiss-Prot : SWS_FT_FI6
49) chain A
residue 67
type SITE
sequence N
description Fine-tunes the proton-transfer properties of H-64; involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962
source Swiss-Prot : SWS_FT_FI6
50) chain A
residue 92
type SITE
sequence Q
description Involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962
source Swiss-Prot : SWS_FT_FI7
51) chain A
residue 2
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P27139
source Swiss-Prot : SWS_FT_FI8
52) chain A
residue 165
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI9
53) chain A
residue 172
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI9

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