eF-site ID 5l6h-A PDB Code 5l6h Chain A click to enlarge Title Uba1 in complex with Ub-ABPA3 covalent adduct Classification LIGASE Compound Ubiquitin-activating enzyme E1 1 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (RS27A_YEAST) Sequence A:  AAGEIDESLYSRQLYVLGKEAMLKMQTSNVLILGLKGLGV EIAKNVVLAGVKSMTVFDPEPVQLADLSTQFFLTEKDIGQ KRGDVTRAKLAELNAYVPVNVLDSLDDVTQLSQFQVVVAT DTVSLEDKVKINEFCHSSGIRFISSETRGLFGNTFVDLGD EFTVLDPTGEEPRTGMVSDIEPDGTVTMLDDNRHGLEDGN FVRFSEVEGLDKLNDGTLFKVEVLGPFAFRIGSVKEYGEY KKGGIFTEVKVPRKISFKSLKQQLSNPEFVFSDFAKFDRA AQLHLGFQALHQFAVRHNGELPRTMNDEDANELIKLVTDL SVQQPEVLGEGVDVNEDLIKELSYQARGDIPGVVAFFGGL VAQEVLKACSGKFTPLKQFMYFDSLESLPDPKNFPRNEKT TQPVNSRYDNQIAVFGLDFQKKIANSKVFLVGSGAIGCEM LKNWALLGLGSGSDGYIVVTDNDSIEKSNLNRQFLFRPKD VGKNKSEVAAEAVCAMNPDLKGKINAKIDKVGPETEEIFN DSFWESLDFVTNALDNVDARTYVDRRCVFYRKPLLESGTL GTKGNTQVIIPRLTESYSSSRDPPEKSIPLCTLRSFPNKI DHTIAWAKSLFQGYFTDSAENVNMYLTQPNFVEQTLKQSG DVKGVLESISDSLSSKPHNFEDCIKWARLEFEKKFNHDIK QLLFNFPKDAKTSNGEPFWSGAKRAPTPLEFDIYNNDHFH FVVAGASLRAYNYGIKSDDSNSKPNVDEYKSVIDHMIIPE FTPNANLKIQVNDDDPDDEIDQLVSSLPDPSTLAGFKLEP VDFEKDDDTNHHIEFITACSNCRAQNYFIETADRQKTKFI AGRIIPAIATTTSLVTGLVNLELYKLIDNKTDIEQYKNGF VNLALPFFGFSEPIASPKGEYNNKKYDKIWDRFDIKGDIK LSDLIEHFEKDEGLEITMLSYGVSLLYASFFPPKKLKERL NLPITQLVKLVTKKDIPAHVSTMILEIXADDKEGEDVEVP FITIHL Description Functional site 1) chain A residue 21 type sequence R description binding site for residue SO4 A 1101 source : AC1 2) chain A residue 478 type sequence N description binding site for residue SO4 A 1101 source : AC1 3) chain A residue 481 type sequence R description binding site for residue SO4 A 1101 source : AC1 4) chain A residue 571 type sequence T description binding site for residue CL A 1102 source : AC2 5) chain A residue 572 type sequence K description binding site for residue CL A 1102 source : AC2 6) chain A residue 861 type sequence R description binding site for residue CL A 1103 source : AC3 7) chain A residue 96 type sequence R description binding site for residue CL A 1104 source : AC4 8) chain A residue 117 type sequence V description binding site for residue CL A 1105 source : AC5 9) chain A residue 282 type sequence D description binding site for residue GOL A 1106 source : AC6 10) chain A residue 285 type sequence K description binding site for residue GOL A 1106 source : AC6 11) chain A residue 391 type sequence F description binding site for residue GOL A 1106 source : AC6 12) chain A residue 392 type sequence D description binding site for residue GOL A 1106 source : AC6 13) chain A residue 393 type sequence S description binding site for residue GOL A 1106 source : AC6 14) chain A residue 395 type sequence E description binding site for residue GOL A 1106 source : AC6 15) chain A residue 908 type sequence F description binding site for residue GOL A 1106 source : AC6 16) chain A residue 288 type sequence R description binding site for residue GOL A 1107 source : AC7 17) chain A residue 344 type sequence N description binding site for residue GOL A 1107 source : AC7 18) chain A residue 394 type sequence L description binding site for residue GOL A 1107 source : AC7 19) chain A residue 137 type sequence K description binding site for residue GOL A 1108 source : AC8 20) chain A residue 153 type sequence S description binding site for residue GOL A 1108 source : AC8 21) chain A residue 155 type sequence E description binding site for residue GOL A 1108 source : AC8 22) chain A residue 162 type sequence N description binding site for residue GOL A 1108 source : AC8 23) chain A residue 811 type sequence L description binding site for residue GOL A 1109 source : AC9 24) chain A residue 813 type sequence G description binding site for residue GOL A 1109 source : AC9 25) chain A residue 814 type sequence F description binding site for residue GOL A 1109 source : AC9 26) chain A residue 819 type sequence V description binding site for residue GOL A 1110 source : AD1 27) chain A residue 828 type sequence N description binding site for residue GOL A 1110 source : AD1 28) chain A residue 830 type sequence H description binding site for residue GOL A 1110 source : AD1 29) chain A residue 713 type sequence R description binding site for residue GOL A 1111 source : AD2 30) chain A residue 24 type sequence Y description binding site for residue GOL A 1112 source : AD3 31) chain A residue 854 type sequence K description binding site for residue GOL A 1112 source : AD3 32) chain A residue 443 type sequence G description binding site for residue 6O2 B 101 source : AD4 33) chain A residue 444 type sequence A description binding site for residue 6O2 B 101 source : AD4 34) chain A residue 470 type sequence D description binding site for residue 6O2 B 101 source : AD4 35) chain A residue 472 type sequence D description binding site for residue 6O2 B 101 source : AD4 36) chain A residue 481 type sequence R description binding site for residue 6O2 B 101 source : AD4 37) chain A residue 482 type sequence Q description binding site for residue 6O2 B 101 source : AD4 38) chain A residue 494 type sequence K description binding site for residue 6O2 B 101 source : AD4 39) chain A residue 520 type sequence V description binding site for residue 6O2 B 101 source : AD4 40) chain A residue 542 type sequence A description binding site for residue 6O2 B 101 source : AD4 41) chain A residue 543 type sequence L description binding site for residue 6O2 B 101 source : AD4 42) chain A residue 544 type sequence D description binding site for residue 6O2 B 101 source : AD4 43) chain A residue 545 type sequence N description binding site for residue 6O2 B 101 source : AD4 44) chain A residue 548 type sequence A description binding site for residue 6O2 B 101 source : AD4 45) chain A residue 944 type sequence E description binding site for residue MG C 1106 source : AD9 46) chain A residue 21 type catalytic sequence R description 307 source MCSA : MCSA1 47) chain A residue 481 type catalytic sequence R description 307 source MCSA : MCSA1 48) chain A residue 544 type catalytic sequence D description 307 source MCSA : MCSA1 49) chain A residue 600 type catalytic sequence C description 307 source MCSA : MCSA1 50) chain A residue 601 type catalytic sequence T description 307 source MCSA : MCSA1 51) chain A residue 603 type catalytic sequence R description 307 source MCSA : MCSA1 52) chain A residue 781 type catalytic sequence N description 307 source MCSA : MCSA1 53) chain A residue 782 type catalytic sequence D description 307 source MCSA : MCSA1 54) chain A residue 600 type catalytic sequence C description 939 source MCSA : MCSA2 55) chain A residue 601 type catalytic sequence T description 939 source MCSA : MCSA2 56) chain A residue 603 type catalytic sequence R description 939 source MCSA : MCSA2 57) chain A residue 781 type catalytic sequence N description 939 source MCSA : MCSA2 58) chain A residue 782 type catalytic sequence D description 939 source MCSA : MCSA2 59) chain A residue 376-384 type prosite sequence KACSGKFTP description UBIQUITIN_ACTIVAT_1 Ubiquitin-activating enzyme signature 1. KACSGKFtP source prosite : PS00536 60) chain A residue 598-606 type prosite sequence PLCTLRSFP description UBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PLCTLRsFP source prosite : PS00865 61) chain A residue 444 type CROSSLNK sequence A description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 62) chain A residue 481 type CROSSLNK sequence R description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 63) chain A residue 544 type CROSSLNK sequence D description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 64) chain A residue 265 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17287358 source Swiss-Prot : SWS_FT_FI4 65) chain A residue 914 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI5 66) chain A residue 595 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI6 67) chain A residue 608 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI6

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