eF-site ID 5l65-Y PDB Code 5l65 Chain Y click to enlarge Title Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence Y:  TTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPY LLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAAS KLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTR LSGQMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSI LAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVK EEEGSFNNVIG Description Functional site 1) chain Y residue 19 type sequence R description binding site for residue MG I 302 source : AC6 2) chain Y residue 164 type sequence A description binding site for residue MG I 302 source : AC6 3) chain Y residue 167 type sequence D description binding site for residue MG I 302 source : AC6 4) chain Y residue 168 type sequence A description binding site for residue MG I 302 source : AC6 5) chain Y residue 170 type sequence S description binding site for residue MG I 302 source : AC6 6) chain Y residue 2 type sequence T description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 7) chain Y residue 3 type sequence T description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 8) chain Y residue 17 type sequence D description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 9) chain Y residue 19 type sequence R description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 10) chain Y residue 20 type sequence A description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 11) chain Y residue 21 type sequence T description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 12) chain Y residue 27 type sequence S description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 13) chain Y residue 33 type sequence K description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 14) chain Y residue 46 type sequence S description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 15) chain Y residue 47 type sequence G description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 16) chain Y residue 49 type sequence A description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 17) chain Y residue 129 type sequence G description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 18) chain Y residue 130 type sequence S description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 19) chain Y residue 131 type sequence G description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 20) chain Y residue 169 type sequence Y description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 21) chain Y residue 170 type sequence S description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE1 22) chain Y residue 2 type sequence T description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 23) chain Y residue 3 type sequence T description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 24) chain Y residue 17 type sequence D description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 25) chain Y residue 19 type sequence R description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 26) chain Y residue 20 type sequence A description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 27) chain Y residue 21 type sequence T description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 28) chain Y residue 27 type sequence S description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 29) chain Y residue 33 type sequence K description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 30) chain Y residue 46 type sequence S description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 31) chain Y residue 47 type sequence G description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 32) chain Y residue 49 type sequence A description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 33) chain Y residue 129 type sequence G description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 34) chain Y residue 130 type sequence S description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 35) chain Y residue 131 type sequence G description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 36) chain Y residue 169 type sequence Y description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2 37) chain Y residue 170 type sequence S description binding site for Di-peptide 3BV Y 301 and THR Y 1 source : AE2

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