eF-site ID 5l65-H PDB Code 5l65 Chain H click to enlarge Title Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence H:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICDIQEE Description Functional site 1) chain H residue 69 type sequence Y description binding site for residue CL G 302 source : AC2 2) chain H residue 1 type sequence T description binding site for residue 3BV H 301 source : AC3 3) chain H residue 19 type sequence R description binding site for residue 3BV H 301 source : AC3 4) chain H residue 20 type sequence S description binding site for residue 3BV H 301 source : AC3 5) chain H residue 21 type sequence T description binding site for residue 3BV H 301 source : AC3 6) chain H residue 22 type sequence Q description binding site for residue 3BV H 301 source : AC3 7) chain H residue 27 type sequence A description binding site for residue 3BV H 301 source : AC3 8) chain H residue 33 type sequence K description binding site for residue 3BV H 301 source : AC3 9) chain H residue 45 type sequence G description binding site for residue 3BV H 301 source : AC3 10) chain H residue 47 type sequence G description binding site for residue 3BV H 301 source : AC3 11) chain H residue 48 type sequence T description binding site for residue 3BV H 301 source : AC3 12) chain H residue 49 type sequence A description binding site for residue 3BV H 301 source : AC3 13) chain H residue 52 type sequence T description binding site for residue 3BV H 301 source : AC3 14) chain H residue 129 type sequence S description binding site for residue 3BV H 301 source : AC3 15) chain H residue 168 type sequence G description binding site for residue 3BV H 301 source : AC3 16) chain H residue 46 type sequence A description binding site for residue MES H 302 source : AC4 17) chain H residue 47 type sequence G description binding site for residue MES H 302 source : AC4 18) chain H residue 129 type sequence S description binding site for residue MES H 302 source : AC4 19) chain H residue 114 type sequence H description binding site for residue 3BV N 201 source : AD1 20) chain H residue 116 type sequence H description binding site for residue 3BV N 201 source : AD1 21) chain H residue 118 type sequence S description binding site for residue 3BV N 201 source : AD1 22) chain H residue 1 type catalytic sequence T description 177 source MCSA : MCSA1 23) chain H residue 17 type catalytic sequence D description 177 source MCSA : MCSA1 24) chain H residue 19 type catalytic sequence R description 177 source MCSA : MCSA1 25) chain H residue 33 type catalytic sequence K description 177 source MCSA : MCSA1 26) chain H residue 47 type catalytic sequence G description 177 source MCSA : MCSA1 27) chain H residue 129 type catalytic sequence S description 177 source MCSA : MCSA1 28) chain H residue 166 type catalytic sequence D description 177 source MCSA : MCSA1 29) chain H residue 169 type catalytic sequence S description 177 source MCSA : MCSA1 30) chain H residue 4-51 type prosite sequence VGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWC AGAGTAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIaGedFAVLAGDtrnitdysinsryep.KvfdcgdnivmsanGfaAD source prosite : PS00854

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