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eF-site ID
|
5l5x-W |
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PDB Code
|
5l5x |
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Chain
|
W |
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click to enlarge
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Title
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Yeast 20S proteasome with human beta5c (1-138) and human beta6 (97-111; 118-133) in complex with ONX 0914 |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Proteasome subunit alpha type-2 |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); |
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Sequence
|
W: |
SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFE
KIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERA
IEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFI
AGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPE
DLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLK
MRQD
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Description
|
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Functional site
|
|
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1)
|
chain |
W |
| residue |
204 |
| type |
|
| sequence |
D
|
| description |
binding site for residue MG K 302
|
| source |
: AD1
|
|
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2)
|
chain |
W |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
binding site for Di-peptide 04C V 301 and THR V 1
|
| source |
: AE1
|
|
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3)
|
chain |
W |
| residue |
126 |
| type |
|
| sequence |
I
|
| description |
binding site for Di-peptide 04C V 301 and THR V 1
|
| source |
: AE1
|
|
|
4)
|
chain |
W |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
binding site for Di-peptide 04C V 301 and THR V 1
|
| source |
: AE2
|
|
|
5)
|
chain |
W |
| residue |
126 |
| type |
|
| sequence |
I
|
| description |
binding site for Di-peptide 04C V 301 and THR V 1
|
| source |
: AE2
|
|
|
6)
|
chain |
W |
| residue |
69 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:19426847
|
| source |
Swiss-Prot : SWS_FT_FI2
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