eF-site ID 5l5x-V PDB Code 5l5x Chain V click to enlarge Title Yeast 20S proteasome with human beta5c (1-138) and human beta6 (97-111; 118-133) in complex with ONX 0914 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence V:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICDIQEE Description Functional site 1) chain V residue 163 type sequence I description binding site for residue MG L 301 source : AD3 2) chain V residue 166 type sequence D description binding site for residue MG L 301 source : AD3 3) chain V residue 169 type sequence S description binding site for residue MG L 301 source : AD3 4) chain V residue 69 type sequence Y description binding site for residue CL U 301 source : AD6 5) chain V residue 47 type sequence G description binding site for residue MES V 302 source : AD7 6) chain V residue 129 type sequence S description binding site for residue MES V 302 source : AD7 7) chain V residue 2 type sequence T description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 8) chain V residue 3 type sequence I description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 9) chain V residue 17 type sequence D description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 10) chain V residue 19 type sequence R description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 11) chain V residue 20 type sequence S description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 12) chain V residue 21 type sequence T description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 13) chain V residue 22 type sequence Q description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 14) chain V residue 31 type sequence C description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 15) chain V residue 33 type sequence K description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 16) chain V residue 45 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 17) chain V residue 46 type sequence A description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 18) chain V residue 47 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 19) chain V residue 48 type sequence T description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 20) chain V residue 49 type sequence A description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 21) chain V residue 52 type sequence T description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 22) chain V residue 128 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 23) chain V residue 129 type sequence S description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 24) chain V residue 130 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 25) chain V residue 168 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 26) chain V residue 169 type sequence S description binding site for Di-peptide 04C V 301 and THR V 1 source : AE1 27) chain V residue 2 type sequence T description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 28) chain V residue 3 type sequence I description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 29) chain V residue 17 type sequence D description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 30) chain V residue 19 type sequence R description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 31) chain V residue 20 type sequence S description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 32) chain V residue 21 type sequence T description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 33) chain V residue 22 type sequence Q description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 34) chain V residue 31 type sequence C description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 35) chain V residue 33 type sequence K description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 36) chain V residue 45 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 37) chain V residue 46 type sequence A description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 38) chain V residue 47 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 39) chain V residue 48 type sequence T description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 40) chain V residue 49 type sequence A description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 41) chain V residue 52 type sequence T description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 42) chain V residue 128 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 43) chain V residue 129 type sequence S description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 44) chain V residue 130 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 45) chain V residue 168 type sequence G description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 46) chain V residue 169 type sequence S description binding site for Di-peptide 04C V 301 and THR V 1 source : AE2 47) chain V residue 1 type catalytic sequence T description 177 source MCSA : MCSA2 48) chain V residue 17 type catalytic sequence D description 177 source MCSA : MCSA2 49) chain V residue 19 type catalytic sequence R description 177 source MCSA : MCSA2 50) chain V residue 33 type catalytic sequence K description 177 source MCSA : MCSA2 51) chain V residue 47 type catalytic sequence G description 177 source MCSA : MCSA2 52) chain V residue 129 type catalytic sequence S description 177 source MCSA : MCSA2 53) chain V residue 166 type catalytic sequence D description 177 source MCSA : MCSA2 54) chain V residue 169 type catalytic sequence S description 177 source MCSA : MCSA2

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