eF-site ID 5l5x-K PDB Code 5l5x Chain K click to enlarge Title Yeast 20S proteasome with human beta5c (1-138) and human beta6 (97-111; 118-133) in complex with ONX 0914 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence K:  TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPY LLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAAS KLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNR ISGATFSVGSGSVYAYGVLDSNYKWDLSVEDALYLGKRSI LAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVK EEEGSFNNVIG Description Functional site 1) chain K residue 1 type sequence T description binding site for residue 04C K 301 source : AC9 2) chain K residue 19 type sequence R description binding site for residue 04C K 301 source : AC9 3) chain K residue 20 type sequence A description binding site for residue 04C K 301 source : AC9 4) chain K residue 21 type sequence T description binding site for residue 04C K 301 source : AC9 5) chain K residue 33 type sequence K description binding site for residue 04C K 301 source : AC9 6) chain K residue 45 type sequence M description binding site for residue 04C K 301 source : AC9 7) chain K residue 47 type sequence G description binding site for residue 04C K 301 source : AC9 8) chain K residue 49 type sequence A description binding site for residue 04C K 301 source : AC9 9) chain K residue 169 type sequence Y description binding site for residue 04C K 301 source : AC9 10) chain K residue 164 type sequence A description binding site for residue MG K 302 source : AD1 11) chain K residue 165 type sequence H description binding site for residue MG K 302 source : AD1 12) chain K residue 167 type sequence D description binding site for residue MG K 302 source : AD1 13) chain K residue 168 type sequence A description binding site for residue MG K 302 source : AD1 14) chain K residue 170 type sequence S description binding site for residue MG K 302 source : AD1 15) chain K residue 47 type sequence G description binding site for residue MES K 303 source : AD2 16) chain K residue 97 type sequence M description binding site for residue MES K 303 source : AD2 17) chain K residue 113 type sequence Y description binding site for residue MES K 303 source : AD2 18) chain K residue 129 type sequence G description binding site for residue MES K 303 source : AD2 19) chain K residue 130 type sequence S description binding site for residue MES K 303 source : AD2 20) chain K residue 49 type BINDING sequence A description BINDING => ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:19426847 source Swiss-Prot : SWS_FT_FI2 21) chain K residue 4-51 type prosite sequence LAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLG TMAGGAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFkFrhGVIVAADsratagayiasqtvk.KvieinpyllgtmaGgaAD source prosite : PS00854

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