eF-site ID 5l5u-b
PDB Code 5l5u
Chain b

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Title Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Proteasome subunit alpha type-2
Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c);
Sequence b:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK
IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS
VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH
KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS
QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL
Description


Functional site
1) chain b
residue 4-51
type prosite
sequence MAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWC
CRSGSAAD
description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFkFqhGVIAAVDsrasagsyisalrmn.KvieinpyllgtmsGcaAD
source prosite : PS00854
2) chain b
residue 1
type ACT_SITE
sequence T
description Nucleophile => ECO:0000269|PubMed:9087403
source Swiss-Prot : SWS_FT_FI1

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