eF-site ID 5l5u-L
PDB Code 5l5u
Chain L

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Title Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Proteasome subunit alpha type-2
Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c);
Sequence L:  QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYE
PKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHN
DKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKG
AVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQY
EPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD
GLEILIVTKDGVRKEFYELKRD
Description


Functional site

1) chain L
residue 124
type
sequence S
description binding site for residue 04C K 301
source : AC8

2) chain L
residue 126
type
sequence D
description binding site for residue 04C K 301
source : AC8

3) chain L
residue 130
type
sequence S
description binding site for residue 04C K 301
source : AC8

4) chain L
residue 137
type
sequence R
description binding site for residue 04C K 301
source : AC8

5) chain L
residue 222
type
sequence D
description binding site for residue MG L 301
source : AD1

6) chain L
residue 13-60
type prosite
sequence LGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVM
SANGFAAD
description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFkFqhGVIAAVDsrasagsyisalrmn.KvieinpyllgtmsGcaAD
source prosite : PS00854


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