eF-site ID 5l5u-H PDB Code 5l5u Chain H click to enlarge Title Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence H:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICDIQEE Description Functional site 1) chain H residue 69 type sequence Y description binding site for residue CL G 302 source : AC3 2) chain H residue 1 type sequence T description binding site for residue 04C H 301 source : AC4 3) chain H residue 20 type sequence S description binding site for residue 04C H 301 source : AC4 4) chain H residue 21 type sequence T description binding site for residue 04C H 301 source : AC4 5) chain H residue 31 type sequence C description binding site for residue 04C H 301 source : AC4 6) chain H residue 45 type sequence G description binding site for residue 04C H 301 source : AC4 7) chain H residue 46 type sequence A description binding site for residue 04C H 301 source : AC4 8) chain H residue 47 type sequence G description binding site for residue 04C H 301 source : AC4 9) chain H residue 49 type sequence A description binding site for residue 04C H 301 source : AC4 10) chain H residue 168 type sequence G description binding site for residue 04C H 301 source : AC4 11) chain H residue 91 type sequence Q description binding site for residue MG N 202 source : AD3 12) chain H residue 4-51 type prosite sequence VGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWC AGAGTAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkFnnGVVIAADtrstqgpivadknca.KlhrispkiwcagaGtaAD source prosite : PS00854 13) chain H residue 1 type catalytic sequence T description 177 source MCSA : MCSA1 14) chain H residue 17 type catalytic sequence D description 177 source MCSA : MCSA1 15) chain H residue 19 type catalytic sequence R description 177 source MCSA : MCSA1 16) chain H residue 33 type catalytic sequence K description 177 source MCSA : MCSA1 17) chain H residue 47 type catalytic sequence G description 177 source MCSA : MCSA1 18) chain H residue 129 type catalytic sequence S description 177 source MCSA : MCSA1 19) chain H residue 166 type catalytic sequence D description 177 source MCSA : MCSA1 20) chain H residue 169 type catalytic sequence S description 177 source MCSA : MCSA1

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