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eF-site ID
|
5l5e-U |
|
PDB Code
|
5l5e |
|
Chain
|
U |
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click to enlarge
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Title
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Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
|
Proteasome subunit alpha type-2 |
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Source
|
null (PSB1_YEAST) |
|
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Sequence
|
U: |
GYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDC
TVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDA
RNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQ
RAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATA
TGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHM
IDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAE
Q
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Description
|
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Functional site
|
|
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1)
|
chain |
U |
| residue |
111 |
| type |
|
| sequence |
R
|
| description |
binding site for residue CL U 301
|
| source |
: AD4
|
|
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2)
|
chain |
U |
| residue |
114 |
| type |
|
| sequence |
N
|
| description |
binding site for residue CL U 301
|
| source |
: AD4
|
|
|
3)
|
chain |
U |
| residue |
223 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
|
| source |
Swiss-Prot : SWS_FT_FI3
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