|
eF-site ID
|
5l5e-P |
PDB Code
|
5l5e |
Chain
|
P |
|
click to enlarge
|
|
Title
|
Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib |
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
Compound
|
Proteasome subunit alpha type-2 |
Source
|
null (PSB1_YEAST) |
|
Sequence
|
P: |
GSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMAS
DGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLT
ADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQG
YTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWK
AISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTT
DSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVK
TGIT
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
P |
residue |
198 |
type |
ACT_SITE |
sequence |
K
|
description |
Nucleophile => ECO:0000269|PubMed:9087403
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
P |
residue |
230 |
type |
ACT_SITE |
sequence |
K
|
description |
Nucleophile => ECO:0000269|PubMed:9087403
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
P |
residue |
99 |
type |
ACT_SITE |
sequence |
K
|
description |
Nucleophile => ECO:0000269|PubMed:9087403
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|