eF-site ID 5l5e-N PDB Code 5l5e Chain N click to enlarge Title Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (PSB1_YEAST) Sequence N:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL Description Functional site 1) chain N residue 1 type sequence T description binding site for residue 3BV N 201 source : AD1 2) chain N residue 20 type sequence T description binding site for residue 3BV N 201 source : AD1 3) chain N residue 21 type sequence T description binding site for residue 3BV N 201 source : AD1 4) chain N residue 22 type sequence T description binding site for residue 3BV N 201 source : AD1 5) chain N residue 45 type sequence R description binding site for residue 3BV N 201 source : AD1 6) chain N residue 46 type sequence S description binding site for residue 3BV N 201 source : AD1 7) chain N residue 47 type sequence G description binding site for residue 3BV N 201 source : AD1 8) chain N residue 49 type sequence A description binding site for residue 3BV N 201 source : AD1 9) chain N residue 129 type sequence S description binding site for residue 3BV N 201 source : AD1 10) chain N residue 168 type sequence S description binding site for residue 3BV N 201 source : AD1 11) chain N residue 19 type sequence R description binding site for residue MG N 202 source : AD2 12) chain N residue 163 type sequence I description binding site for residue MG N 202 source : AD2 13) chain N residue 166 type sequence D description binding site for residue MG N 202 source : AD2 14) chain N residue 169 type sequence S description binding site for residue MG N 202 source : AD2 15) chain N residue 31 type sequence T description binding site for residue CL N 203 source : AD3 16) chain N residue 45 type sequence R description binding site for residue CL N 203 source : AD3 17) chain N residue 53 type sequence Q description binding site for residue CL N 203 source : AD3 18) chain N residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000269|PubMed:9087403 source Swiss-Prot : SWS_FT_FI1

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