eF-site ID 5l5e-L PDB Code 5l5e Chain L click to enlarge Title Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (PSB1_YEAST) Sequence L:  QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYE PKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHN DKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKG AVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQY EPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD GLEILIVTKDGVRKEFYELKRD Description Functional site 1) chain L residue 106 type sequence Y description binding site for residue 3BV K 301 source : AC8 2) chain L residue 127 type sequence P description binding site for residue 3BV K 301 source : AC8 3) chain L residue 33 type sequence Y description binding site for residue MES V 302 source : AD5 4) chain L residue 13-60 type prosite sequence LGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVM SANGFAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIaGedFAVLAGDtrnitdysinsryep.KvfdcgdnivmsanGfaAD source prosite : PS00854

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