|
eF-site ID
|
5l5e-J |
PDB Code
|
5l5e |
Chain
|
J |
|
click to enlarge
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Title
|
Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib |
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
Compound
|
Proteasome subunit alpha type-2 |
Source
|
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (PSB1_YEAST) |
|
Sequence
|
J: |
MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSP
HTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAV
SSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQID
YLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDL
LKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDF
|
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Description
|
|
Functional site
|
|
1)
|
chain |
J |
residue |
118 |
type |
|
sequence |
Q
|
description |
binding site for residue MG J 201
|
source |
: AC7
|
|
2)
|
chain |
J |
residue |
124 |
type |
|
sequence |
T
|
description |
binding site for residue MG J 201
|
source |
: AC7
|
|
3)
|
chain |
J |
residue |
76 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
J |
residue |
5-52 |
type |
prosite |
sequence |
LGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLM
SFAGEAGD
|
description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIrVqdSVILASSkavtrgisvlkdsdd.KtrqlsphtlmsfaGeaGD
|
source |
prosite : PS00854
|
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