eF-site ID 5l5e-J
PDB Code 5l5e
Chain J

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Title Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Proteasome subunit alpha type-2
Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (PSB1_YEAST)
Sequence J:  MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSP
HTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAV
SSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQID
YLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDL
LKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDF
Description


Functional site

1) chain J
residue 118
type
sequence Q
description binding site for residue MG J 201
source : AC7

2) chain J
residue 124
type
sequence T
description binding site for residue MG J 201
source : AC7

3) chain J
residue 76
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:18407956
source Swiss-Prot : SWS_FT_FI2

4) chain J
residue 5-52
type prosite
sequence LGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLM
SFAGEAGD
description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIrVqdSVILASSkavtrgisvlkdsdd.KtrqlsphtlmsfaGeaGD
source prosite : PS00854


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