eF-site ID 5l5e-B PDB Code 5l5e Chain B click to enlarge Title Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (PSB1_YEAST) Sequence B:  GSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMAS DGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLT ADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQG YTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWK AISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTT DSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVK TGIT Description Functional site 1) chain B residue 198 type ACT_SITE sequence K description Nucleophile => ECO:0000269|PubMed:9087403 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 230 type ACT_SITE sequence K description Nucleophile => ECO:0000269|PubMed:9087403 source Swiss-Prot : SWS_FT_FI1 3) chain B residue 35-82 type prosite sequence IGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAV AVAGLTAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIrVqdSVILASSkavtrgisvlkdsdd.KtrqlsphtlmsfaGeaGD source prosite : PS00854 4) chain B residue 5-27 type prosite sequence YDSRTTIFSPEGRLYQVEYALES description PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdgdtVtFSPtGRlfQVEYAleA source prosite : PS00388

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