eF-site ID 5kup-A PDB Code 5kup Chain A click to enlarge Title Bruton's tyrosine kinase (BTK) with pyridazinone compound 9 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tyrosine-protein kinase BTK Source Homo sapiens (Human) (BTK_HUMAN) Sequence A:  SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIK EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFII TEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTS SVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL GKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC WHEKADERPTFKILLSNILDVMDEN Description Functional site 1) chain A residue 466 type sequence K description binding site for residue SO4 A 701 source : AC1 2) chain A residue 490 type sequence R description binding site for residue SO4 A 701 source : AC1 3) chain A residue 592 type sequence S description binding site for residue SO4 A 702 source : AC2 4) chain A residue 595 type sequence K description binding site for residue SO4 A 702 source : AC2 5) chain A residue 617 type sequence Y description binding site for residue SO4 A 702 source : AC2 6) chain A residue 619 type sequence P description binding site for residue SO4 A 702 source : AC2 7) chain A residue 620 type sequence H description binding site for residue SO4 A 702 source : AC2 8) chain A residue 443 type sequence I description binding site for residue GOL A 703 source : AC3 9) chain A residue 444 type sequence E description binding site for residue GOL A 703 source : AC3 10) chain A residue 562 type sequence R description binding site for residue GOL A 703 source : AC3 11) chain A residue 599 type sequence E description binding site for residue GOL A 703 source : AC3 12) chain A residue 600 type sequence R description binding site for residue GOL A 703 source : AC3 13) chain A residue 601 type sequence F description binding site for residue GOL A 703 source : AC3 14) chain A residue 602 type sequence T description binding site for residue GOL A 703 source : AC3 15) chain A residue 520 type sequence R description binding site for residue GOL A 704 source : AC4 16) chain A residue 543 type sequence S description binding site for residue GOL A 704 source : AC4 17) chain A residue 551 type sequence Y description binding site for residue GOL A 704 source : AC4 18) chain A residue 559 type sequence F description binding site for residue GOL A 704 source : AC4 19) chain A residue 560 type sequence P description binding site for residue GOL A 704 source : AC4 20) chain A residue 574 type sequence F description binding site for residue GOL A 704 source : AC4 21) chain A residue 425 type sequence Y description binding site for residue PG0 A 705 source : AC5 22) chain A residue 461 type sequence Y description binding site for residue PG0 A 705 source : AC5 23) chain A residue 617 type sequence Y description binding site for residue PG0 A 705 source : AC5 24) chain A residue 408 type sequence L description binding site for residue 6XL A 706 source : AC6 25) chain A residue 410 type sequence T description binding site for residue 6XL A 706 source : AC6 26) chain A residue 411 type sequence G description binding site for residue 6XL A 706 source : AC6 27) chain A residue 413 type sequence F description binding site for residue 6XL A 706 source : AC6 28) chain A residue 416 type sequence V description binding site for residue 6XL A 706 source : AC6 29) chain A residue 428 type sequence A description binding site for residue 6XL A 706 source : AC6 30) chain A residue 430 type sequence K description binding site for residue 6XL A 706 source : AC6 31) chain A residue 474 type sequence T description binding site for residue 6XL A 706 source : AC6 32) chain A residue 475 type sequence E description binding site for residue 6XL A 706 source : AC6 33) chain A residue 476 type sequence Y description binding site for residue 6XL A 706 source : AC6 34) chain A residue 477 type sequence M description binding site for residue 6XL A 706 source : AC6 35) chain A residue 478 type sequence A description binding site for residue 6XL A 706 source : AC6 36) chain A residue 480 type sequence G description binding site for residue 6XL A 706 source : AC6 37) chain A residue 528 type sequence L description binding site for residue 6XL A 706 source : AC6 38) chain A residue 538 type sequence S description binding site for residue 6XL A 706 source : AC6 39) chain A residue 539 type sequence D description binding site for residue 6XL A 706 source : AC6 40) chain A residue 543 type sequence S description binding site for residue 6XL A 706 source : AC6 41) chain A residue 551 type sequence Y description binding site for residue 6XL A 706 source : AC6 42) chain A residue 623 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15375214 source Swiss-Prot : SWS_FT_FI8 43) chain A residue 625 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI9 44) chain A residue 408-430 type prosite sequence LGTGQFGVVKYGKWRGQYDVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK source prosite : PS00107 45) chain A residue 517-529 type prosite sequence FLHRDLAARNCLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV source prosite : PS00109 46) chain A residue 521 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 430 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 408 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 474 type BINDING sequence T description BINDING => ECO:0000269|PubMed:20052711, ECO:0007744|PDB:3K54, ECO:0007744|PDB:3OCT source Swiss-Prot : SWS_FT_FI3 50) chain A residue 542 type BINDING sequence L description BINDING => ECO:0000269|PubMed:21280133, ECO:0007744|PDB:3PIY source Swiss-Prot : SWS_FT_FI4 51) chain A residue 551 type MOD_RES sequence Y description Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8630736, ECO:0000269|PubMed:9012831 source Swiss-Prot : SWS_FT_FI5 52) chain A residue 604 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 53) chain A residue 617 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:15375214 source Swiss-Prot : SWS_FT_FI7

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