eF-site ID 5ksi-C PDB Code 5ksi Chain C click to enlarge Title Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate Classification OXYGEN TRANSPORT Compound Hemoglobin subunit alpha Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence C:  VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTK TYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR Description Functional site 1) chain C residue 32 type sequence M description binding site for residue HEM C 201 source : AC6 2) chain C residue 42 type sequence Y description binding site for residue HEM C 201 source : AC6 3) chain C residue 43 type sequence F description binding site for residue HEM C 201 source : AC6 4) chain C residue 45 type sequence H description binding site for residue HEM C 201 source : AC6 5) chain C residue 46 type sequence F description binding site for residue HEM C 201 source : AC6 6) chain C residue 58 type sequence H description binding site for residue HEM C 201 source : AC6 7) chain C residue 61 type sequence K description binding site for residue HEM C 201 source : AC6 8) chain C residue 83 type sequence L description binding site for residue HEM C 201 source : AC6 9) chain C residue 86 type sequence L description binding site for residue HEM C 201 source : AC6 10) chain C residue 87 type sequence H description binding site for residue HEM C 201 source : AC6 11) chain C residue 91 type sequence L description binding site for residue HEM C 201 source : AC6 12) chain C residue 93 type sequence V description binding site for residue HEM C 201 source : AC6 13) chain C residue 97 type sequence N description binding site for residue HEM C 201 source : AC6 14) chain C residue 98 type sequence F description binding site for residue HEM C 201 source : AC6 15) chain C residue 101 type sequence L description binding site for residue HEM C 201 source : AC6 16) chain C residue 136 type sequence L description binding site for residue HEM C 201 source : AC6 17) chain C residue 36 type sequence F description binding site for residue S1P C 202 source : AC7 18) chain C residue 99 type sequence K description binding site for residue S1P C 202 source : AC7 19) chain C residue 100 type sequence L description binding site for residue S1P C 202 source : AC7 20) chain C residue 103 type sequence H description binding site for residue S1P C 202 source : AC7 21) chain C residue 41 type sequence T description binding site for residue S1P C 203 source : AC8 22) chain C residue 42 type sequence Y description binding site for residue S1P C 203 source : AC8 23) chain C residue 44 type sequence P description binding site for residue S1P C 203 source : AC8 24) chain C residue 90 type sequence K description binding site for residue S1P C 203 source : AC8 25) chain C residue 91 type sequence L description binding site for residue S1P C 203 source : AC8 26) chain C residue 92 type sequence R description binding site for residue S1P C 203 source : AC8 27) chain C residue 72 type sequence H description binding site for residue HEM D 201 source : AC9 28) chain C residue 72 type sequence H description binding site for residue S1P D 202 source : AD1 29) chain C residue 108 type MOD_RES sequence T description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI11 30) chain C residue 134 type MOD_RES sequence T description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI11 31) chain C residue 137 type MOD_RES sequence T description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI11 32) chain C residue 7 type CARBOHYD sequence K description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI12 33) chain C residue 16 type CARBOHYD sequence K description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI12 34) chain C residue 40 type CARBOHYD sequence K description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI12 35) chain C residue 8 type BINDING sequence T description proximal binding residue source Swiss-Prot : SWS_FT_FI3 36) chain C residue 13 type BINDING sequence A description proximal binding residue source Swiss-Prot : SWS_FT_FI3 37) chain C residue 24 type BINDING sequence Y description proximal binding residue source Swiss-Prot : SWS_FT_FI3 38) chain C residue 29 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 39) chain C residue 45 type BINDING sequence H description proximal binding residue source Swiss-Prot : SWS_FT_FI3 40) chain C residue 47 type BINDING sequence D description proximal binding residue source Swiss-Prot : SWS_FT_FI3 41) chain C residue 52 type BINDING sequence S description proximal binding residue source Swiss-Prot : SWS_FT_FI3 42) chain C residue 55 type BINDING sequence V description proximal binding residue source Swiss-Prot : SWS_FT_FI3 43) chain C residue 59 type BINDING sequence G description proximal binding residue source Swiss-Prot : SWS_FT_FI3 44) chain C residue 91 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 45) chain C residue 106 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 46) chain C residue 108 type BINDING sequence T description proximal binding residue source Swiss-Prot : SWS_FT_FI3 47) chain C residue 121 type BINDING sequence V description proximal binding residue source Swiss-Prot : SWS_FT_FI3 48) chain C residue 133 type BINDING sequence S description proximal binding residue source Swiss-Prot : SWS_FT_FI3 49) chain C residue 7 type MOD_RES sequence K description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 50) chain C residue 16 type MOD_RES sequence K description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 51) chain C residue 40 type MOD_RES sequence K description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 52) chain C residue 102 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 53) chain C residue 124 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 54) chain C residue 131 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 55) chain C residue 138 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10

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