eF-site ID 5kce-B PDB Code 5kce Chain B click to enlarge Title Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with an N-methyl, 2-chlorobenzyl OBHS-N derivative Classification TRANSCRIPTION Compound Estrogen receptor Source Homo sapiens (Human) (NCOA2_HUMAN) Sequence B:  SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMG LLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWL EILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEI FDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSS TLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRL AQLLLILSHIRHMSNKGMEHLYSMKPLSDLLLEMLDAHR Description Functional site 1) chain B residue 343 type sequence M description binding site for residue OB3 B 601 source : AC3 2) chain B residue 346 type sequence L description binding site for residue OB3 B 601 source : AC3 3) chain B residue 347 type sequence T description binding site for residue OB3 B 601 source : AC3 4) chain B residue 353 type sequence E description binding site for residue OB3 B 601 source : AC3 5) chain B residue 387 type sequence L description binding site for residue OB3 B 601 source : AC3 6) chain B residue 388 type sequence M description binding site for residue OB3 B 601 source : AC3 7) chain B residue 394 type sequence R description binding site for residue OB3 B 601 source : AC3 8) chain B residue 404 type sequence F description binding site for residue OB3 B 601 source : AC3 9) chain B residue 418 type sequence V description binding site for residue OB3 B 601 source : AC3 10) chain B residue 419 type sequence E description binding site for residue OB3 B 601 source : AC3 11) chain B residue 420 type sequence G description binding site for residue OB3 B 601 source : AC3 12) chain B residue 421 type sequence M description binding site for residue OB3 B 601 source : AC3 13) chain B residue 424 type sequence I description binding site for residue OB3 B 601 source : AC3 14) chain B residue 521 type sequence G description binding site for residue OB3 B 601 source : AC3 15) chain B residue 524 type sequence H description binding site for residue OB3 B 601 source : AC3 16) chain B residue 525 type sequence L description binding site for residue OB3 B 601 source : AC3 17) chain B residue 358-423 type DNA_BIND sequence INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSME HPGKLLFAPNLLLDRNQGKCVEGMVE description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 358-378 type ZN_FING sequence INWAKRVPGFVDLTLHDQVHL description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 394-418 type ZN_FING sequence RSMEHPGKLLFAPNLLLDRNQGKCV description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 526 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI3 21) chain B residue 340 type MOD_RES sequence A description Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153 source Swiss-Prot : SWS_FT_FI4 22) chain B residue 433 type MOD_RES sequence S description Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420 source Swiss-Prot : SWS_FT_FI5

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