eF-site ID 5kce-A PDB Code 5kce Chain A click to enlarge Title Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with an N-methyl, 2-chlorobenzyl OBHS-N derivative Classification TRANSCRIPTION Compound Estrogen receptor Source Homo sapiens (Human) (NCOA2_HUMAN) Sequence A:  KNSLALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLAD RELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGL VWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLAT SSRFRMMNLQGEEFVCLKSIILLNSGDHIHRVLDKITDTL IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLY SMKCKNVVPLSDLLLEMLDAHRL Description Functional site 1) chain A residue 343 type sequence M description binding site for residue OB3 A 601 source : AC1 2) chain A residue 347 type sequence T description binding site for residue OB3 A 601 source : AC1 3) chain A residue 353 type sequence E description binding site for residue OB3 A 601 source : AC1 4) chain A residue 387 type sequence L description binding site for residue OB3 A 601 source : AC1 5) chain A residue 388 type sequence M description binding site for residue OB3 A 601 source : AC1 6) chain A residue 394 type sequence R description binding site for residue OB3 A 601 source : AC1 7) chain A residue 404 type sequence F description binding site for residue OB3 A 601 source : AC1 8) chain A residue 419 type sequence E description binding site for residue OB3 A 601 source : AC1 9) chain A residue 420 type sequence G description binding site for residue OB3 A 601 source : AC1 10) chain A residue 421 type sequence M description binding site for residue OB3 A 601 source : AC1 11) chain A residue 424 type sequence I description binding site for residue OB3 A 601 source : AC1 12) chain A residue 521 type sequence G description binding site for residue OB3 A 601 source : AC1 13) chain A residue 524 type sequence H description binding site for residue OB3 A 601 source : AC1 14) chain A residue 525 type sequence L description binding site for residue OB3 A 601 source : AC1 15) chain A residue 528 type sequence M description binding site for residue OB3 A 601 source : AC1 16) chain A residue 536 type sequence L description binding site for residue OB3 A 601 source : AC1 17) chain A residue 343 type sequence M description binding site for residue OB3 A 602 source : AC2 18) chain A residue 347 type sequence T description binding site for residue OB3 A 602 source : AC2 19) chain A residue 353 type sequence E description binding site for residue OB3 A 602 source : AC2 20) chain A residue 387 type sequence L description binding site for residue OB3 A 602 source : AC2 21) chain A residue 388 type sequence M description binding site for residue OB3 A 602 source : AC2 22) chain A residue 394 type sequence R description binding site for residue OB3 A 602 source : AC2 23) chain A residue 404 type sequence F description binding site for residue OB3 A 602 source : AC2 24) chain A residue 424 type sequence I description binding site for residue OB3 A 602 source : AC2 25) chain A residue 521 type sequence G description binding site for residue OB3 A 602 source : AC2 26) chain A residue 524 type sequence H description binding site for residue OB3 A 602 source : AC2 27) chain A residue 525 type sequence L description binding site for residue OB3 A 602 source : AC2 28) chain A residue 528 type sequence M description binding site for residue OB3 A 602 source : AC2 29) chain A residue 536 type sequence L description binding site for residue OB3 A 602 source : AC2 30) chain A residue 433 type MOD_RES sequence S description Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420 source Swiss-Prot : SWS_FT_FI4 31) chain A residue 358-423 type DNA_BIND sequence INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSME HPGKLLFAPNLLLDRNQGKCVEGMVE description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 358-378 type ZN_FING sequence INWAKRVPGFVDLTLHDQVHL description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 394-418 type ZN_FING sequence RSMEHPGKLLFAPNLLLDRNQGKCV description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2

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