eF-site ID 5kal-ABYZ PDB Code 5kal Chain A, B, Y, Z click to enlarge Title Terminal uridylyl transferase 4 from Trypanosoma brucei with bound UTP and UpU Classification Transferase/RNA Compound RNA uridylyltransferase 4 Source Trypanosoma brucei (5KAL) Sequence A:  PPSPAVVGRSLVNSFKQFVSHVDATYRLVLDCVAAVDPLM RLYTFGSTVVYGVHEKGSDVDFVVLNKTDVEDGKGGDAAT QVAKGLQADILAKLARVIRQKHLSWNVEEVRRTRVPVVRV KGGGAVDFDITAYRRNGVRNSALLRAYFEQNPPCRWLSMS IKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQRNHLQF VPPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLHF FLHEFDSDKQVISLNRPGITTKEELDWTKSAEDFARMNGE KVHYQWCIEDPYELNLNVGRNVTPLKRDFLRRHLEKARDT ALLTI B:  PPSPAVVGRSLVNSFKVDATYRLVLDCVAAVDPLMRLYTF GSTVVYGVHEKGSDVDFVVLNKTDVEDGKGGDAATQVAKG LQADILAKLARVIRQKHLSWNVEEVRRTRVPVVRVKGDFD ITAYRRNGVRNSALLRAYFEQNPPCRWLSMSIKRWSKQTG LNASVIGGSITSYGFNLMVVYYLLQRNHLQFVPPSTIDVS RVEPLPPHLPLEEPADEGLELGTQVLDFLHFFLHEFDSDK QVISLNRPGITTKEELDWTKSAEDFARMNGEKVHYQWCIE DPYELNLNVGRNVTPLKRDFLRRHLEKARDTALLTI Y:  UU Z:  UU Description Functional site 1) chain A residue 52 type sequence F description binding site for residue UTP A 501 source : AC1 2) chain A residue 54 type sequence S description binding site for residue UTP A 501 source : AC1 3) chain A residue 65 type sequence S description binding site for residue UTP A 501 source : AC1 4) chain A residue 66 type sequence D description binding site for residue UTP A 501 source : AC1 5) chain A residue 68 type sequence D description binding site for residue UTP A 501 source : AC1 6) chain A residue 144 type sequence G description binding site for residue UTP A 501 source : AC1 7) chain A residue 147 type sequence N description binding site for residue UTP A 501 source : AC1 8) chain A residue 148 type sequence S description binding site for residue UTP A 501 source : AC1 9) chain A residue 169 type sequence K description binding site for residue UTP A 501 source : AC1 10) chain A residue 173 type sequence K description binding site for residue UTP A 501 source : AC1 11) chain A residue 188 type sequence S description binding site for residue UTP A 501 source : AC1 12) chain A residue 189 type sequence Y description binding site for residue UTP A 501 source : AC1 13) chain Y residue 2 type sequence U description binding site for residue UTP A 501 source : AC1 14) chain A residue 66 type sequence D description binding site for residue MG A 502 source : AC2 15) chain A residue 68 type sequence D description binding site for residue MG A 502 source : AC2 16) chain B residue 52 type sequence F description binding site for residue UTP B 401 source : AC3 17) chain B residue 54 type sequence S description binding site for residue UTP B 401 source : AC3 18) chain B residue 65 type sequence S description binding site for residue UTP B 401 source : AC3 19) chain B residue 66 type sequence D description binding site for residue UTP B 401 source : AC3 20) chain B residue 68 type sequence D description binding site for residue UTP B 401 source : AC3 21) chain B residue 144 type sequence G description binding site for residue UTP B 401 source : AC3 22) chain B residue 147 type sequence N description binding site for residue UTP B 401 source : AC3 23) chain B residue 148 type sequence S description binding site for residue UTP B 401 source : AC3 24) chain B residue 169 type sequence K description binding site for residue UTP B 401 source : AC3 25) chain B residue 173 type sequence K description binding site for residue UTP B 401 source : AC3 26) chain B residue 188 type sequence S description binding site for residue UTP B 401 source : AC3 27) chain B residue 189 type sequence Y description binding site for residue UTP B 401 source : AC3 28) chain Z residue 2 type sequence U description binding site for residue UTP B 401 source : AC3 29) chain B residue 66 type sequence D description binding site for residue MG B 402 source : AC4 30) chain B residue 68 type sequence D description binding site for residue MG B 402 source : AC4 31) chain B residue 66 type sequence D description binding site for residue MG B 403 source : AC5 32) chain B residue 126 type sequence R description binding site for residue MG B 403 source : AC5 33) chain B residue 136 type sequence D description binding site for residue MG B 403 source : AC5 34) chain Y residue 2 type sequence U description binding site for residue MG Y 101 source : AC6 35) chain Z residue 2 type sequence U description binding site for residue MG Z 101 source : AC7 36) chain A residue 121 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI3 37) chain B residue 121 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI3 38) chain B residue 169 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 39) chain B residue 173 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 40) chain B residue 188 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 41) chain B residue 54 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 42) chain B residue 65 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 43) chain B residue 144 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 44) chain A residue 169 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 45) chain A residue 173 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 46) chain A residue 188 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 47) chain A residue 54 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 48) chain A residue 65 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 49) chain A residue 144 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 50) chain A residue 66 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2NOM, ECO:0007744|PDB:2Q0C, ECO:0007744|PDB:2Q0D, ECO:0007744|PDB:2Q0E, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI2 51) chain A residue 68 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2NOM, ECO:0007744|PDB:2Q0C, ECO:0007744|PDB:2Q0D, ECO:0007744|PDB:2Q0E, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI2 52) chain B residue 66 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2NOM, ECO:0007744|PDB:2Q0C, ECO:0007744|PDB:2Q0D, ECO:0007744|PDB:2Q0E, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI2 53) chain B residue 68 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2NOM, ECO:0007744|PDB:2Q0C, ECO:0007744|PDB:2Q0D, ECO:0007744|PDB:2Q0E, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI2 54) chain A residue 136 type SITE sequence D description Important for catalytic activity => ECO:0000269|PubMed:17189640 source Swiss-Prot : SWS_FT_FI4 55) chain B residue 136 type SITE sequence D description Important for catalytic activity => ECO:0000269|PubMed:17189640 source Swiss-Prot : SWS_FT_FI4

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