eF-site ID 5k8x-D PDB Code 5k8x Chain D click to enlarge Title Crystal structure of mouse CARM1 in complex with inhibitor U3 Classification TRANSFERASE Compound Histone-arginine methyltransferase CARM1 Source Mus musculus (Mouse) (CARM1_MOUSE) Sequence D:  RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQ RAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAV EASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDI IISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVH LAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDE YFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIP FKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLT HWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIV AQVDQTGSKSSNLLDLKNPFFR Description Functional site 1) chain D residue 316 type sequence Q description binding site for residue DXE C 508 source : AE3 2) chain D residue 472 type sequence N description binding site for residue DXE C 509 source : AE4 3) chain D residue 150 type sequence Y description binding site for residue 6ZH D 501 source : AE6 4) chain D residue 151 type sequence F description binding site for residue 6ZH D 501 source : AE6 5) chain D residue 154 type sequence Y description binding site for residue 6ZH D 501 source : AE6 6) chain D residue 193 type sequence G description binding site for residue 6ZH D 501 source : AE6 7) chain D residue 215 type sequence E description binding site for residue 6ZH D 501 source : AE6 8) chain D residue 216 type sequence A description binding site for residue 6ZH D 501 source : AE6 9) chain D residue 241 type sequence G description binding site for residue 6ZH D 501 source : AE6 10) chain D residue 242 type sequence K description binding site for residue 6ZH D 501 source : AE6 11) chain D residue 243 type sequence V description binding site for residue 6ZH D 501 source : AE6 12) chain D residue 244 type sequence E description binding site for residue 6ZH D 501 source : AE6 13) chain D residue 258 type sequence E description binding site for residue 6ZH D 501 source : AE6 14) chain D residue 260 type sequence M description binding site for residue 6ZH D 501 source : AE6 15) chain D residue 267 type sequence E description binding site for residue 6ZH D 501 source : AE6 16) chain D residue 269 type sequence M description binding site for residue 6ZH D 501 source : AE6 17) chain D residue 272 type sequence S description binding site for residue 6ZH D 501 source : AE6 18) chain D residue 404 type sequence W description binding site for residue EDO D 502 source : AE7 19) chain D residue 409 type sequence P description binding site for residue EDO D 505 source : AE9 20) chain D residue 410 type sequence T description binding site for residue EDO D 505 source : AE9 21) chain D residue 411 type sequence E description binding site for residue EDO D 505 source : AE9 22) chain D residue 162 type sequence N description binding site for residue DXE D 507 source : AF1 23) chain D residue 415 type sequence H description binding site for residue DXE D 507 source : AF1 24) chain D residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 source Swiss-Prot : SWS_FT_FI3 25) chain D residue 193 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 215 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 244 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 272 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 160 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 169 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2

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