eF-site ID 5k8x-C PDB Code 5k8x Chain C click to enlarge Title Crystal structure of mouse CARM1 in complex with inhibitor U3 Classification TRANSFERASE Compound Histone-arginine methyltransferase CARM1 Source Mus musculus (Mouse) (CARM1_MOUSE) Sequence C:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRY Description Functional site 1) chain C residue 178 type sequence L description binding site for residue EDO B 503 source : AD3 2) chain C residue 205 type sequence Q description binding site for residue EDO B 503 source : AD3 3) chain C residue 150 type sequence Y description binding site for residue 6ZH C 501 source : AD6 4) chain C residue 151 type sequence F description binding site for residue 6ZH C 501 source : AD6 5) chain C residue 154 type sequence Y description binding site for residue 6ZH C 501 source : AD6 6) chain C residue 193 type sequence G description binding site for residue 6ZH C 501 source : AD6 7) chain C residue 215 type sequence E description binding site for residue 6ZH C 501 source : AD6 8) chain C residue 216 type sequence A description binding site for residue 6ZH C 501 source : AD6 9) chain C residue 241 type sequence G description binding site for residue 6ZH C 501 source : AD6 10) chain C residue 242 type sequence K description binding site for residue 6ZH C 501 source : AD6 11) chain C residue 243 type sequence V description binding site for residue 6ZH C 501 source : AD6 12) chain C residue 244 type sequence E description binding site for residue 6ZH C 501 source : AD6 13) chain C residue 258 type sequence E description binding site for residue 6ZH C 501 source : AD6 14) chain C residue 260 type sequence M description binding site for residue 6ZH C 501 source : AD6 15) chain C residue 267 type sequence E description binding site for residue 6ZH C 501 source : AD6 16) chain C residue 269 type sequence M description binding site for residue 6ZH C 501 source : AD6 17) chain C residue 272 type sequence S description binding site for residue 6ZH C 501 source : AD6 18) chain C residue 410 type sequence T description binding site for residue EDO C 502 source : AD7 19) chain C residue 284 type sequence G description binding site for residue PEG C 504 source : AD8 20) chain C residue 398 type sequence G description binding site for residue PEG C 504 source : AD8 21) chain C residue 399 type sequence S description binding site for residue PEG C 504 source : AD8 22) chain C residue 333 type sequence D description binding site for residue PEG C 505 source : AD9 23) chain C residue 424 type sequence Q description binding site for residue PEG C 505 source : AD9 24) chain C residue 404 type sequence W description binding site for residue PEG C 506 source : AE1 25) chain C residue 277 type sequence K description binding site for residue DXE C 507 source : AE2 26) chain C residue 280 type sequence L description binding site for residue DXE C 507 source : AE2 27) chain C residue 282 type sequence P description binding site for residue DXE C 507 source : AE2 28) chain C residue 361 type sequence L description binding site for residue DXE C 507 source : AE2 29) chain C residue 165 type sequence Q description binding site for residue DXE C 508 source : AE3 30) chain C residue 153 type sequence F description binding site for residue DXE C 509 source : AE4 31) chain C residue 159 type sequence Q description binding site for residue DXE C 509 source : AE4 32) chain C residue 262 type sequence Y description binding site for residue M2M C 510 source : AE5 33) chain C residue 267 type sequence E description binding site for residue M2M C 510 source : AE5 34) chain C residue 160 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 35) chain C residue 169 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 36) chain C residue 193 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 37) chain C residue 215 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 38) chain C residue 244 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 39) chain C residue 272 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 40) chain C residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 41) chain C residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 source Swiss-Prot : SWS_FT_FI3

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