eF-site ID 5k8x-B PDB Code 5k8x Chain B click to enlarge Title Crystal structure of mouse CARM1 in complex with inhibitor U3 Classification TRANSFERASE Compound Histone-arginine methyltransferase CARM1 Source Mus musculus (Mouse) (CARM1_MOUSE) Sequence B:  RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQ RAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAV EASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDI IISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVH LAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDE YFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIP FKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLT HWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIV AQVDQTGSKSSNLLDLKNPFFRY Description Functional site 1) chain B residue 136 type sequence S description binding site for residue PE8 A 509 source : AC9 2) chain B residue 244 type sequence E description binding site for residue PE8 A 509 source : AC9 3) chain B residue 245 type sequence E description binding site for residue PE8 A 509 source : AC9 4) chain B residue 247 type sequence S description binding site for residue PE8 A 509 source : AC9 5) chain B residue 251 type sequence Q description binding site for residue PE8 A 509 source : AC9 6) chain B residue 279 type sequence Y description binding site for residue PE8 A 509 source : AC9 7) chain B residue 150 type sequence Y description binding site for residue 6ZH B 501 source : AD1 8) chain B residue 151 type sequence F description binding site for residue 6ZH B 501 source : AD1 9) chain B residue 154 type sequence Y description binding site for residue 6ZH B 501 source : AD1 10) chain B residue 193 type sequence G description binding site for residue 6ZH B 501 source : AD1 11) chain B residue 215 type sequence E description binding site for residue 6ZH B 501 source : AD1 12) chain B residue 216 type sequence A description binding site for residue 6ZH B 501 source : AD1 13) chain B residue 241 type sequence G description binding site for residue 6ZH B 501 source : AD1 14) chain B residue 242 type sequence K description binding site for residue 6ZH B 501 source : AD1 15) chain B residue 243 type sequence V description binding site for residue 6ZH B 501 source : AD1 16) chain B residue 244 type sequence E description binding site for residue 6ZH B 501 source : AD1 17) chain B residue 258 type sequence E description binding site for residue 6ZH B 501 source : AD1 18) chain B residue 267 type sequence E description binding site for residue 6ZH B 501 source : AD1 19) chain B residue 269 type sequence M description binding site for residue 6ZH B 501 source : AD1 20) chain B residue 272 type sequence S description binding site for residue 6ZH B 501 source : AD1 21) chain B residue 147 type sequence A description binding site for residue EDO B 502 source : AD2 22) chain B residue 242 type sequence K description binding site for residue EDO B 502 source : AD2 23) chain B residue 458 type sequence D description binding site for residue EDO B 503 source : AD3 24) chain B residue 415 type sequence H description binding site for residue EDO B 504 source : AD4 25) chain B residue 267 type sequence E description binding site for residue DXE B 506 source : AD5 26) chain B residue 428 type sequence F description binding site for residue DXE C 508 source : AE3 27) chain B residue 215 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 244 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 272 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 160 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 169 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 193 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 source Swiss-Prot : SWS_FT_FI3

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