eF-site ID 5k2c-A PDB Code 5k2c Chain A click to enlarge Title 1.9 angstrom A2a adenosine receptor structure with sulfur SAD phasing and phase extension using XFEL data Classification MEMBRANE PROTEIN Compound Adenosine receptor A2a/Soluble cytochrome b562 chimera Source (AA2AR_HUMAN) Sequence A:  DGAPPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNL QNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGC LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVT GTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQ GCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVY LRIFLAARRQLADLEDNWETLNDNLKVIEKADNAAQVKDA LTKMRAAALDAQKATPEMKDFRHGFDILVGQIDDALKLAN EGKVKEAQAAAEQLKTTRNAYIQKYLERARSTLQKEVHAA KSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYL AIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVL Description (1)  Adenosine receptor A2a/Soluble cytochrome b562 chimera Functional site 1) chain A residue 168 type sequence F description binding site for residue ZMA A 1201 source : AC1 2) chain A residue 169 type sequence E description binding site for residue ZMA A 1201 source : AC1 3) chain A residue 177 type sequence M description binding site for residue ZMA A 1201 source : AC1 4) chain A residue 246 type sequence W description binding site for residue ZMA A 1201 source : AC1 5) chain A residue 249 type sequence L description binding site for residue ZMA A 1201 source : AC1 6) chain A residue 250 type sequence H description binding site for residue ZMA A 1201 source : AC1 7) chain A residue 253 type sequence N description binding site for residue ZMA A 1201 source : AC1 8) chain A residue 270 type sequence M description binding site for residue ZMA A 1201 source : AC1 9) chain A residue 52 type sequence D description binding site for residue NA A 1202 source : AC2 10) chain A residue 91 type sequence S description binding site for residue NA A 1202 source : AC2 11) chain A residue 72 type sequence A description binding site for residue CLR A 1203 source : AC3 12) chain A residue 73 type sequence A description binding site for residue CLR A 1203 source : AC3 13) chain A residue 80 type sequence I description binding site for residue CLR A 1203 source : AC3 14) chain A residue 262 type sequence C description binding site for residue CLR A 1204 source : AC4 15) chain A residue 263 type sequence S description binding site for residue CLR A 1204 source : AC4 16) chain A residue 70 type sequence F description binding site for residue OLC A 1206 source : AC6 17) chain A residue 31 type sequence V description binding site for residue OLC A 1208 source : AC8 18) chain A residue 32 type sequence W description binding site for residue OLC A 1208 source : AC8 19) chain A residue 46 type sequence V description binding site for residue OLC A 1208 source : AC8 20) chain A residue 43 type sequence Y description binding site for residue OLC A 1209 source : AC9 21) chain A residue 122 type sequence K description binding site for residue OLC A 1209 source : AC9 22) chain A residue 125 type sequence I description binding site for residue OLC A 1209 source : AC9 23) chain A residue 129 type sequence W description binding site for residue OLC A 1209 source : AC9 24) chain A residue 140 type sequence M description binding site for residue OLC A 1210 source : AD1 25) chain A residue 141 type sequence L description binding site for residue OLC A 1210 source : AD1 26) chain A residue 179 type sequence Y description binding site for residue OLC A 1210 source : AD1 27) chain A residue 184 type sequence A description binding site for residue OLC A 1210 source : AD1 28) chain A residue 64 type sequence I description binding site for residue OLC A 1211 source : AD2 29) chain A residue 65 type sequence T description binding site for residue OLC A 1211 source : AD2 30) chain A residue 6 type sequence S description binding site for residue OLC A 1213 source : AD4 31) chain A residue 67 type sequence S description binding site for residue OLC A 1213 source : AD4 32) chain A residue 267 type sequence L description binding site for residue OLC A 1213 source : AD4 33) chain A residue 268 type sequence W description binding site for residue OLA A 1215 source : AD6 34) chain A residue 290 type sequence Y description binding site for residue OLA A 1216 source : AD7 35) chain A residue 10 type sequence I description binding site for residue OLA A 1218 source : AD9 36) chain A residue 7 type sequence S description binding site for residue OLA A 1219 source : AE1 37) chain A residue 11 type sequence T description binding site for residue OLA A 1219 source : AE1 38) chain A residue 97 type sequence A description binding site for residue OLA A 1220 source : AE2 39) chain A residue 128 type sequence C description binding site for residue OLA A 1220 source : AE2 40) chain A residue 179 type sequence Y description binding site for residue OLA A 1221 source : AE3 41) chain A residue 258 type sequence F description binding site for residue OLA A 1221 source : AE3 42) chain A residue 244 type sequence L description binding site for residue OLA A 1222 source : AE4 43) chain A residue 7 type sequence S description binding site for residue OLA A 1223 source : AE5 44) chain A residue 29 type sequence W description binding site for residue OLA A 1223 source : AE5 45) chain A residue 286 type sequence F description binding site for residue OLA A 1223 source : AE5 46) chain A residue 29 type sequence W description binding site for residue OLA A 1225 source : AE7 47) chain A residue 32 type sequence W description binding site for residue OLA A 1225 source : AE7 48) chain A residue 201 type sequence F description binding site for residue OLA A 1225 source : AE7 49) chain A residue 229 type sequence V description binding site for residue OLA A 1225 source : AE7 50) chain A residue 233 type sequence K description binding site for residue OLA A 1225 source : AE7 51) chain A residue 120 type sequence R description binding site for residue PEG A 1226 source : AE8 52) chain A residue 123 type sequence G description binding site for residue PEG A 1226 source : AE8 53) chain A residue 127 type sequence I description binding site for residue PEG A 1226 source : AE8 54) chain A residue 258 type sequence F description binding site for residue OLC A 1227 source : AE9 55) chain A residue 90-106 type prosite sequence SSIFSLLAIAIDRYIAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI source prosite : PS00237 56) chain A residue 8-32 type TRANSMEM sequence VYITVELAIAVLAILGNVLVCWAVW description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 57) chain A residue 169 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO source Swiss-Prot : SWS_FT_FI10 58) chain A residue 253 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO source Swiss-Prot : SWS_FT_FI10 59) chain A residue 277 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO source Swiss-Prot : SWS_FT_FI10 60) chain A residue 278 type BINDING sequence H description BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO source Swiss-Prot : SWS_FT_FI10 61) chain A residue 154 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI11 62) chain A residue 1007 type BINDING sequence W description axial binding residue source Swiss-Prot : SWS_FT_FI12 63) chain A residue 1102 type BINDING sequence I description axial binding residue source Swiss-Prot : SWS_FT_FI12 64) chain A residue 33-42 type TOPO_DOM sequence LNSNLQNVTN description Cytoplasmic => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI2 65) chain A residue 101-120 type TOPO_DOM sequence DRYIAIRIPLRYNGLVTGTR description Cytoplasmic => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 43-66 type TRANSMEM sequence YFVVSLAAADIAVGVLAIPFAITI description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 67) chain A residue 67-77 type TOPO_DOM sequence STGFCAACHGC description Extracellular => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI4 68) chain A residue 144-173 type TOPO_DOM sequence NNCGQPKEGKNHSQGCGEGQVACLFEDVVP description Extracellular => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI4 69) chain A residue 259-266 type TOPO_DOM sequence CPDCSHAP description Extracellular => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI4 70) chain A residue 78-100 type TRANSMEM sequence LFIACFVLVLTQSSIFSLLAIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 71) chain A residue 121-143 type TRANSMEM sequence AKGIIAICWVLSFAIGLTPMLGW description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 72) chain A residue 174-198 type TRANSMEM sequence MNYMVYFNFFACVLVPLLLMLGVYL description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 73) chain A residue 235-258 type TRANSMEM sequence LAIIVGLFALCWLPLHIINCFTFF description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 74) chain A residue 267-290 type TRANSMEM sequence LWLMYLAIVLSHTNSVVNPFIYAY description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9

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