eF-site ID 5k0k-B PDB Code 5k0k Chain B click to enlarge Title Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434 Classification Transferase/Transferase Inhibitor Compound Tyrosine-protein kinase Mer Source Homo sapiens (Human) (MERTK_HUMAN) Sequence B:  LEDVVIDRNLLILGKILGEGGSVMEGNLKQEDGTSLKVAV KTEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFM KYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYL SNRNFLHRDLAARNCMLRDDMTVCVADFPVKWIAIESLAD RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLL HGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQL EKLLESLP Description Functional site 1) chain B residue 687 type sequence R description binding site for residue CL A 905 source : AC5 2) chain B residue 584 type sequence R description binding site for residue CL B 901 source : AC6 3) chain B residue 588 type sequence I description binding site for residue CL B 901 source : AC6 4) chain B residue 589 type sequence L description binding site for residue CL B 901 source : AC6 5) chain B residue 819 type sequence L description binding site for residue CL B 902 source : AC7 6) chain B residue 820 type sequence K description binding site for residue CL B 902 source : AC7 7) chain B residue 728 type sequence N description binding site for residue MG B 903 source : AC8 8) chain B residue 741 type sequence D description binding site for residue MG B 903 source : AC8 9) chain B residue 591 type sequence K description binding site for residue 6Q1 B 904 source : AC9 10) chain B residue 601 type sequence V description binding site for residue 6Q1 B 904 source : AC9 11) chain B residue 617 type sequence A description binding site for residue 6Q1 B 904 source : AC9 12) chain B residue 672 type sequence P description binding site for residue 6Q1 B 904 source : AC9 13) chain B residue 673 type sequence F description binding site for residue 6Q1 B 904 source : AC9 14) chain B residue 674 type sequence M description binding site for residue 6Q1 B 904 source : AC9 15) chain B residue 675 type sequence K description binding site for residue 6Q1 B 904 source : AC9 16) chain B residue 730 type sequence M description binding site for residue 6Q1 B 904 source : AC9 17) chain B residue 741 type sequence D description binding site for residue 6Q1 B 904 source : AC9 18) chain B residue 723 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 593 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 615 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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