|
|
eF-site ID
|
5juy-A |
|
PDB Code
|
5juy |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Active human apoptosome with procaspase-9 |
|
Classification
|
APOPTOSIS |
|
Compound
|
Apoptotic protease-activating factor 1 |
|
Source
|
ORGANISM_COMMON: Bovine; ORGANISM_SCIENTIFIC: Bos taurus; |
|
|
Sequence
|
A: |
GITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLK
GEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHW
VSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAK
DRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTT
RDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKA
DLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQ
LQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYT
DLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLL
FCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQF
QRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALM
FSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENF
QEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQA
KQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFS
EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCA
FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNC
CHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTN
SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK
QFFLNEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTS
GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNT
DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW
ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLI
NGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILE
LVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV
WNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKV
WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA
KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNG
EIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDG
KMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDF
KTYVTVDNLGILYILQTLE
|
|
|
Description
|
(1) |
Apoptotic protease-activating factor 1, Cytochrome c, Caspase-9 (E.C.3.4.22.62)
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
672-686 |
| type |
prosite |
| sequence |
IATCSVDKKVKIWNS
|
| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATCsvDkKVKIWNS
|
| source |
prosite : PS00678
|
|
|
2)
|
chain |
A |
| residue |
716-730 |
| type |
prosite |
| sequence |
LATGSSDCFLKLWDL
|
| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATCsvDkKVKIWNS
|
| source |
prosite : PS00678
|
|
|
3)
|
chain |
A |
| residue |
758-772 |
| type |
prosite |
| sequence |
LASCSADGTLKLWDA
|
| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATCsvDkKVKIWNS
|
| source |
prosite : PS00678
|
|
|
4)
|
chain |
A |
| residue |
1142-1156 |
| type |
prosite |
| sequence |
LATGDDNGEIRIWNV
|
| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATCsvDkKVKIWNS
|
| source |
prosite : PS00678
|
|
|
|