|
|
eF-site ID
|
5jiy-F |
|
PDB Code
|
5jiy |
|
Chain
|
F |
|
click to enlarge
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Title
|
Structure of G9a SET-domain with Histone H3K9norLeucine mutant peptide and bound S-adenosylmethionine |
|
Classification
|
TRANSFERASE |
|
Compound
|
Histone-lysine N-methyltransferase EHMT2 |
|
Source
|
Homo sapiens (Human) (5JIY) |
|
|
Sequence
|
F: |
KQTARXST
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
F |
| residue |
9 |
| type |
|
| sequence |
X
|
| description |
binding site for residue SAM A 1205
|
| source |
: AC5
|
|
|
2)
|
chain |
F |
| residue |
4 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
F |
| residue |
5 |
| type |
MOD_RES |
| sequence |
Q
|
| description |
5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
F |
| residue |
6 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
5)
|
chain |
F |
| residue |
10 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
6)
|
chain |
F |
| residue |
8 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
7)
|
chain |
F |
| residue |
9 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
8)
|
chain |
F |
| residue |
11 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
|