|
|
eF-site ID
|
5j9q-E |
|
PDB Code
|
5j9q |
|
Chain
|
E |
|
click to enlarge
|
|
|
Title
|
Crystal structure of the NuA4 core complex |
|
Classification
|
TRANSFERASE |
|
Compound
|
Histone acetyltransferase ESA1 |
|
Source
|
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (5J9Q) |
|
|
Sequence
|
E: |
SMTQNPHEVARVRNLNRIIMGKYEIEPWYFSPYPIELTDE
DFIYIDDFTLQYFGSKKQYERYRKKCTLRHPPGNEIYRDD
YVSFFEIDGRKQRTWCRNLCLLSKLFLDHXTLYYDVDPFL
FYCMTRRDELGHHLVGYFSKEKESADGYNVACILTLPQYQ
RMGYGKLLIEFSYELSKKENKVGSPQKPLSDLGLLSYRAY
WSDTLITLLVEHQKEITIDEISSMTSMTTTDILHTAKTLN
ILRYYKGQHIIFLNEDILDRYNRLKAKKRRTIDPNRLIWK
PPVFTASQLRFAW
|
|
|
Description
|
(1) |
Histone acetyltransferase ESA1 (E.C.2.3.1.48), Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, Chromatin modification-related protein YNG2, Htz1
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
304 |
| type |
catalytic |
| sequence |
C
|
| description |
525
|
| source |
MCSA : MCSA1
|
|
|
2)
|
chain |
E |
| residue |
338 |
| type |
catalytic |
| sequence |
Q
|
| description |
525
|
| source |
MCSA : MCSA1
|
|
|
3)
|
chain |
E |
| residue |
338 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton donor/acceptor => ECO:0000303|PubMed:12368900, ECO:0000303|PubMed:17223684, ECO:0000303|PubMed:18245364, ECO:0000303|PubMed:22020126, ECO:0000305
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
E |
| residue |
303 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
E |
| residue |
312 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
E |
| residue |
342 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
E |
| residue |
304 |
| type |
SITE |
| sequence |
C
|
| description |
Important for catalytic activity => ECO:0000305
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
8)
|
chain |
E |
| residue |
262 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:22020126
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|