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eF-site ID
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5j9q-A |
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PDB Code
|
5j9q |
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Chain
|
A |
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click to enlarge
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Title
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Crystal structure of the NuA4 core complex |
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Classification
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TRANSFERASE |
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Compound
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Histone acetyltransferase ESA1 |
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Source
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Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (5J9Q) |
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Sequence
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A: |
MTQNPHEVARVRNLNRIIMGKYEIEPWYFSPYPIELTDED
FIYIDDFTLQYFGSKKQYERYRKKCTLRHPPGNEIYRDDY
VSFFEIDGRKQRTWCRNLCLLSKLFLDHXTLYYDVDPFLF
YCMTRRDELGHHLVGYFSKEKESADGYNVACILTLPQYQR
MGYGKLLIEFSYELSKKENKVGSPQKPLSDLGLLSYRAYW
SDTLITLLVEHQKEITIDEISSMTSMTTTDILHTAKTLNI
LRYYKGQHIIFLNEDILDRYNRLKAKKRRTIDPNRLIWKP
PVFTASQLRFAW
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Description
|
(1) |
Histone acetyltransferase ESA1 (E.C.2.3.1.48), Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, Chromatin modification-related protein YNG2, Htz1
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Functional site
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1)
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chain |
A |
| residue |
304 |
| type |
catalytic |
| sequence |
C
|
| description |
525
|
| source |
MCSA : MCSA2
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2)
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chain |
A |
| residue |
338 |
| type |
catalytic |
| sequence |
Q
|
| description |
525
|
| source |
MCSA : MCSA2
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3)
|
chain |
A |
| residue |
338 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton donor/acceptor => ECO:0000303|PubMed:12368900, ECO:0000303|PubMed:17223684, ECO:0000303|PubMed:18245364, ECO:0000303|PubMed:22020126, ECO:0000305
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| source |
Swiss-Prot : SWS_FT_FI2
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|
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4)
|
chain |
A |
| residue |
303 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126
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| source |
Swiss-Prot : SWS_FT_FI3
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|
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5)
|
chain |
A |
| residue |
312 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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6)
|
chain |
A |
| residue |
342 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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7)
|
chain |
A |
| residue |
304 |
| type |
SITE |
| sequence |
C
|
| description |
Important for catalytic activity => ECO:0000305
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| source |
Swiss-Prot : SWS_FT_FI4
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8)
|
chain |
A |
| residue |
262 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:22020126
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| source |
Swiss-Prot : SWS_FT_FI5
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