eF-site ID 5j3x-F PDB Code 5j3x Chain F click to enlarge Title Structure of c-CBL Y371F Classification LIGASE Compound E3 ubiquitin-protein ligase CBL Source Homo sapiens (Human) (CBL_HUMAN) Sequence F:  TVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLP DTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQT ISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIF PSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQAL HEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQ PWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPG SYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALI DGFREGFYLFPDGRNQNPDLTGLCEPTDHIKVTQEQYELF CEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQES EGQGCPFCRCEIKGTEPIVVDPFD Description Functional site 1) chain F residue 381 type sequence C description binding site for residue ZN F 501 source : AD7 2) chain F residue 384 type sequence C description binding site for residue ZN F 501 source : AD7 3) chain F residue 401 type sequence C description binding site for residue ZN F 501 source : AD7 4) chain F residue 404 type sequence C description binding site for residue ZN F 501 source : AD7 5) chain F residue 396 type sequence C description binding site for residue ZN F 502 source : AD8 6) chain F residue 398 type sequence H description binding site for residue ZN F 502 source : AD8 7) chain F residue 416 type sequence C description binding site for residue ZN F 502 source : AD8 8) chain F residue 419 type sequence C description binding site for residue ZN F 502 source : AD8 9) chain F residue 229 type sequence D description binding site for residue CA F 503 source : AD9 10) chain F residue 231 type sequence T description binding site for residue CA F 503 source : AD9 11) chain F residue 233 type sequence N description binding site for residue CA F 503 source : AD9 12) chain F residue 235 type sequence Y description binding site for residue CA F 503 source : AD9 13) chain F residue 240 type sequence E description binding site for residue CA F 503 source : AD9 14) chain F residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 15) chain F residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 16) chain F residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 17) chain F residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 18) chain F residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 19) chain F residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 20) chain F residue 371 type MOD_RES sequence F description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 21) chain F residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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